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Y0001578

西地那非

Name: 西地那非
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

西地那非柠檬酸盐, 1-[[3-（4,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-d]嘧啶-5-基）-4-乙氧基苯基]磺酰基]-4-甲基哌嗪柠檬酸盐, 5-[2-乙氧基-5-（4-甲基哌嗪-1-基）磺酰基苯基] -1-甲基-3-丙基-4H-吡唑并[5,4-e]嘧啶-7-酮柠檬酸盐, UK-92,480, 西地那非

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关于此项目

经验公式（希尔记法）:

C₂₂H₃₀N₆O₄S ·C₆H₈O₇

化学文摘社编号:

171599-83-0

分子量:

666.70

NACRES:

NA.24

PubChem Substance ID:

329831492

UNSPSC Code:

41116107

MDL number:

MFCD09026931

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属性

grade

pharmaceutical primary standard

API family

sildenafil

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4

InChI

1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Gene Information

human ... PDE5A(8654)

说明

General description

本品按现行药典规定交付。所有为支持本产品而提供的信息，包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持，请访问现行药典网站。

Application

西地那非柠檬酸盐EP参考标准品的预期用途是欧洲药典规定的实验室测试。

Biochem/physiol Actions

西地那非是cGMP特异性5型磷酸二酯酶（PDE5）的一种有效选择性抑制剂。西地那非可用于治疗勃起功能障碍和肺动脉高压。

西地那非是cGMP特异性5型磷酸二酯酶（PDE5）的一种有效选择性抑制剂。西地那非可用于治疗勃起功能障碍和肺动脉高压。NO可激活鸟苷酸环化酶，从而导致cGMP水平增加并产生平滑肌松弛。西地那非可通过抑制负责cGMP降解的PDE5来增强NO的作用。

Packaging

本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。

Other Notes

可能适用相应的销售限制。

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of sildenafil treatment on patients with Peyronie's disease and erectile dysfunction.

U Ozturk et al.

Irish journal of medical science, 183(3), 449-453 (2013-11-06)

It has been shown on experimental rat models that type 5-phosphodiesterase isoenzyme (PDE5) inhibitors have anti-fibrotic effects for Peyronie's disease (PD); however, this issue has not been addressed clinically. The aim of this study was to document the effects of

Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application.

M Paranjpe et al.

International journal of pharmaceutics, 476(1-2), 41-49 (2014-09-28)

For the development of any colloidal system, thorough characterization is extremely essential. This article discusses the physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) including stability analysis over 6 months time period for possible pulmonary administration for the treatment

Sildenafil alters retinal function in mouse carriers of retinitis pigmentosa.

Lisa Nivison-Smith et al.

Experimental eye research, 128, 43-56 (2014-09-23)

Sildenafil, the active ingredient in Viagra, has been reported to cause transient visual disturbance from inhibition of phosphodiesterase 6 (PDE6), a key enzyme in the visual phototransduction pathway. This study investigated the effects of sildenafil on the rd1(+/-) mouse, a

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全球贸易项目编号

货号	GTIN
Y0001578	04061837584930