氯仿

氯仿是一种卤化烃，广泛用作各种制造和实验室程序中的溶剂和萃取剂。它可以通过甲烷或低氯化甲烷的氯化反应产生。此外，它还用于生产二氯羰基、α-三氯甲基甲醇和三氯硫代类羰基。

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氯仿可作为溶剂用于：

• 通过 ω-十五内酯的酶催化开环聚合制备聚酯
• 通过 Pd 催化的氯化物与芳基硼酸交叉偶联反应合成二芳基酮。
• 通过 α-芳基亚硝基甲烷与氨基砜的对映和非对映选择性硝基-曼尼希反应合成β-硝基胺。
• 通过狄尔斯-阿德尔反应合成螺融合二氢丙酮。氯仿和羰基氧间形成的氢键（CH-O）使羰基成为更强的异二亲试剂，从而提高了反应速率。