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05288

K-252a

Name: K-252a
Brand: SIGMA

from Nocardiopsis sp.

别名:

Protein kinase inhibitor

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关于此项目

经验公式（希尔记法）:

C₂₇H₂₁N₃O₅

化学文摘社编号:

99533-80-9

分子量:

467.47

NACRES:

NA.85

PubChem Substance ID:

329747678

UNSPSC Code:

12352200

MDL number:

MFCD00161522

Form:

powder

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属性

biological source

Nocardiopsis sp.

form

powder

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

Gene Information

human ... NTRK1(4914)
rat ... Prkca(24680)

说明

Application

K-252a用于抑制参与细胞信号传导过程的蛋白激酶，包括CaM激酶；磷酸化酶激酶，丝氨酸/苏氨酸激酶，Trk。它用于抑制神经生长因子（NGF）对PC1 2细胞的作用，并抑制平滑肌肌球蛋白轻链激酶。

Biochem/physiol Actions

多种蛋白激酶（包括蛋白激酶A，C和G）的有效抑制剂。据报道，它选择性地抑制神经生长因子（NGF）对PC1 2细胞的作用，并已显示出抑制平滑肌肌球蛋白轻链激酶的作用。

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pictograms

GHS08

signalword

Danger

hcodes

H360D,H371

pcodes

P202 - P260 - P264 - P280 - P308 + P311 - P405

Hazard Classifications

Repr. 1B - STOT SE 2

target_organs

Eyes,Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

BCCD6165

BCBV8342

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K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells.

S Koizumi et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 8(2), 715-721 (1988-02-01)

K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252a prevents neurite generation initiated by NGF, but not

K-252a, a novel microbial product, inhibits smooth muscle myosin light chain kinase.

S Nakanishi et al.

The Journal of biological chemistry, 263(13), 6215-6219 (1988-05-05)

Effects of K-252a, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8, 11-epoxy-1H,8H,11H-2,7b,11a-triazadibenzo[a,g]cycloocta [cde]trinden-1-one, purified from the culture broth of Nocardiopsis sp., on the activity of myosin light chain kinase were investigated. 1) K-252a (1 x 10(-5) M) affected three characteristic properties of chicken gizzard myosin-B

A new antibiotic SF-2370 produced by Actinomadura.

M Sezaki et al.

The Journal of antibiotics, 38(10), 1437-1439 (1985-10-01)

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货号	GTIN
05288-100UG-F	04061838637277