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Kolliphor P 188

Name: Kolliphor P 188
Brand: SIGMA

别名:

聚（乙二醇）- 嵌段 - 聚（丙二醇）- 嵌段 - 聚（乙二醇）, Lutrol F68, 泊洛沙姆188

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关于此项目

化学文摘社编号:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

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属性

form

solid

Quality Level

200

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤5 ppm propylene oxide, ≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH₃OH

pH

5.0-7.5 (100 g/L in H₂O), 6.0-7.5 (25 g/L in H₂O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

说明

Application

P 188在牙科制剂中的稳定作用：研究P188对smartCrystal牙科用橙皮苷工业浓缩液的稳定作用，发现其可提高制剂的长期稳定性，有牙科治疗意义(Romero et al., 2015)。

Biochem/physiol Actions

Poloxamer 188广泛用作增稠剂和凝胶粘合剂。

Other Notes

Poloxamer 188是广泛的嵌段共聚物系列泊洛沙姆(poloxamer)的一种型号。

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存储类别

11 - Combustible Solids

wgk

WGK 1

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Aggregation behaviors of PEO-PPO-ph-PPO-PEO and PPO-PEO-ph-PEO-PPO at an air/water interface: experimental study and molecular dynamics simulation.

Houjian Gong et al.

Langmuir : the ACS journal of surfaces and colloids, 28(38), 13590-13600 (2012-09-08)

The block polyethers PEO-PPO-ph-PPO-PEO (BPE) and PPO-PEO-ph-PEO-PPO (BEP) are synthesized by anionic polymerization using bisphenol A as initiator. Compared with Pluronic P123, the aggregation behaviors of BPE and BEP at an air/water interface are investigated by the surface tension and

Combined pluronic P85- and ultrasound contrast agents-mediated gene transfection to HepG2 cells.

Xijun Zhang et al.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)

This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report

[Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo studies)].

A N Sklifas et al.

Biofizika, 57(2), 317-324 (2012-05-19)

The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with

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