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22620

奎宁

Name: 奎宁
Brand: SIGMA

suitable for fluorescence, anhydrous, ≥98.0% (dried material, NT)

别名:

6′-甲氧基辛可宁

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₄N₂O₂

化学文摘社编号:

130-95-0

分子量:

324.42

UNSPSC Code:

12171500

NACRES:

NA.32

PubChem Substance ID:

57647993

EC Number:

205-003-2

Beilstein/REAXYS Number:

91867

MDL number:

MFCD00198096

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属性

Quality Level

100

assay

≥98.0% (dried material, NT)

form

powder

optical activity

[α]20/D −126±5°, c = 1% in chloroform

impurities

≤5% dihydroquinine (HPLC)

loss

≤1% loss on drying, 110 °C

mp

173-175 °C (lit.)

solubility

H₂O: soluble

fluorescence

λ_ex 347 nm; λ_em 448 nm in 0.5 M sulfuric acid

suitability

suitable for fluorescence

SMILES string

COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1

InChI key

LOUPRKONTZGTKE-WZBLMQSHSA-N

Gene Information

human ... ABCB1(5243), CYP2C9(1559), CYP2D6(1565)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

说明

General description

Quinine, also known as 6′-Methoxycinchonidine is a fluorescent reagent. The quantum yield of Quinine is 23% higher at 390 mµ excitation wavelength than at 313 mµ. The fluorescence polarization in the emission band of quinine in a rigid medium arises from two singlet states simultaneously. The emission spectra of quinine or 6-methoxyquinoline shifts towards the red zone when excited at 390 mµ.

Application

Quinine was used in the following processes:

To study its in vitro antimalarial activity in combination with omeprazole.
To analyze its effect on viscosity and friction of saliva.
As a test agent to study its impact on the accumulation of the fluorescent P-glycoprotein (Pgp) substrates in P-glycoprotein overexpressing breast cancer cells.
To study its influence on the pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity in vitro.
As a reference compound to identify alkaloids by phytochemical screening of Deianira erubescens, Strychnos pseudoquina and Remijia ferruginea plants.

Biochem/physiol Actions

钾通道阻断剂。

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

存储类别

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

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The role of friction in perceived oral texture.

Rene A. de Wijk , Jon F. Prinz.

Food Quality and Preference, 16, 121-129 (2005)

A.A. Smaardijk et al.

The Journal of Organic Chemistry, 52, 135-135 (1987)

Dimeric Cinchona alkaloids.

Przemysław J Boratyński

Molecular diversity, 19(2), 385-422 (2015-01-15)

Nature is full of dimeric alkaloids of various types from many plant families, some of them with interesting biological properties. However, dimeric Cinchona alkaloids were not isolated from any species but were products of designed partial chemical synthesis. Although the

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全球贸易项目编号

货号	GTIN
22620-100G	04061833379431
22620-25G	04061838780119
22620-5G	04061838780126