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238422

2-溴十六烷酸

Name: 2-溴十六烷酸
Brand: SIGMA

~97%, PPARδ agonist, solid

别名:

2-溴棕榈酸

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关于此项目

线性分子式:

CH₃(CH₂)₁₃CH(Br)CO₂H

化学文摘社编号:

18263-25-7

分子量:

335.32

NACRES:

NA.77

PubChem Substance ID:

57648040

UNSPSC Code:

12352203

EC Number:

242-137-0

MDL number:

MFCD00004215

Beilstein/REAXYS Number:

1726517

Assay:

~97%

Form:

solid

Quality level:

100

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属性

产品名称

2-溴十六烷酸, ~97%

assay

~97%

Quality Level

100

form

solid

SMILES string

CCCCCCCCCCCCCCC(Br)C(O)=O

InChI

1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)

InChI key

DPRAYRYQQAXQPE-UHFFFAOYSA-N

Gene Information

human ... PPARD(5467)

说明

General description

PPARδ（过氧化物酶体增殖物激活受体，δ 同种型）作为基因表达的一种转录因子，并在脂质代谢调节中发挥作用；该受体的活性受配体调节。2-溴十六烷酸是脂肪酸棕榈酸的代谢稳定的类似物，已被证明是 PPARδ 受体的天然配体。2-溴十六烷酸也已被用在脂肪酸氧化、棕榈酰化和葡萄糖摄取的研究中。

Biochem/physiol Actions

溴十六烷酸是 PPARδ 激动剂。它还显示抑制脂肪酸氧化，抑制 DHHC 介导的棕榈酰化，并促进大鼠心脏细胞和胰岛素敏感的鼠成纤维细胞系 A31-IS 中的葡萄糖摄取。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The mechanisms of action of PPARs.

Joel Berger et al.

Annual review of medicine, 53, 409-435 (2002-01-31)

The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes. PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements (PPREs)

Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane.

Pedro E Marques et al.

Developmental cell, 50(3), 283-295 (2019-06-25)

Scavenger receptor B1 (SR-B1), the main receptor for high-density lipoprotein (HDL), is key in preventing atherosclerosis. It removes cholesterol from HDL, returning the lipid-poor lipoprotein to the circulation. To study the mechanisms controlling SR-B1 dynamics at the plasma membrane and

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.

Abiy M Mohammed et al.

Biochemical pharmacology, 85(1), 109-114 (2012-10-25)

Phagocyte-like NADPH oxidase (Nox2) has been shown to play regulatory roles in the metabolic dysfunction of the islet β-cell under the duress of glucolipotoxic conditions and exposure to proinflammatory cytokines. However, the precise mechanisms underlying Nox2 activation by these stimuli

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全球贸易项目编号

货号	GTIN
238422-10G	04061833480090
238422-50G	04061833463659