Glycophorin A (GA-R2) Mouse Monoclonal Antibody

Glycophorins A (GPA) and B (GPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and SU blood groups. Glycophorins span the membrane and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion thus minimizing aggregation between red blood cells in the circulation. Anti-glycophorin A has been used to characterize erythroid cell development and in the diagnosis of erythroid leukemias.

Glycophorins A and B are major sialoglycoproteins expressed across the surface of the human erythrocyte membrane and contain the antigenic determinants that define the MNS blood group system. The high sialic acid content of glycophorin A contributes to the generation of a net negative surface charge across erythrocyte membranes that minimizes interactions between red blood cells and prevents their aggregation. Anti-glycophorin A has utility in identifying cells of the erythroid lineage.

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

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Glycophorin A Positive Control Slides, Product No. 260S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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