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高良姜黄素

Name: 高良姜黄素
Brand: SIGMA

autophagy inducing flavonoid

别名:

3,5,7-三羟基黄酮, 高良姜黄素

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₀O₅

化学文摘社编号:

548-83-4

分子量:

270.24

UNSPSC Code:

41116107

NACRES:

NA.79

PubChem Substance ID:

57648294

EC Number:

208-960-4

Beilstein/REAXYS Number:

272179

MDL number:

MFCD00006833

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属性

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

yellow

mp

214-215 °C (lit.)

SMILES string

Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H

InChI key

VCCRNZQBSJXYJD-UHFFFAOYSA-N

Gene Information

human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)

说明

General description

高良姜精是从姜科家族成员中分离出的一种类黄酮，主要用作草药。

Application

高良姜素已用于:

作为试验药物用于测试其在顺铂诱导的肾毒性啮齿动物模型中的改善作用
测试其对3T3-L1前脂肪细胞向脂肪细胞分化的影响
作为核磁共振波谱和质谱的内标物

Biochem/physiol Actions

高良姜精具有抗氧化、抗凋亡、抗炎和抗肥胖特性。此外，它还具有抵抗环境和饮食致癌物的抗遗传毒性。高良姜精通过阻止癌细胞增殖、诱导凋亡和自噬以及抑制转移来抑制癌细胞生长。高良姜精还具有抑制CYP1A1（细胞色素P450，家族成员1A1）活性的能力。

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study.

Carina Proença et al.

Journal of enzyme inhibition and medicinal chemistry, 32(1), 1216-1228 (2017-09-22)

α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus. As flavonoids are promising modulators of this enzyme's activity, a panel of 44

Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents.

Jung-Jin Lee et al.

Scientific reports, 7(1), 8207-8207 (2017-08-16)

In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

Ciolino HP and Yeh GC

British Journal of Cancer, 79(9), 1340-1340 (1999)

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