biological source
ox bile
Quality Level
description
anionic
assay
≥99.0% (T)
form
powder
optical activity
[α]20/D +54±1°, c = 1% in ethanol
mol wt
392.57 g/mol
impurities
≤1% cholic acid (TLC)
mp
170-175 °C, 171-174 °C (lit.)
functional group
carboxylic acid
SMILES string
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI
1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChI key
KXGVEGMKQFWNSR-LLQZFEROSA-N
Gene Information
human ... ATIC(471)
General description
脱氧胆酸是一种两亲分子,是胆汁酸的重要组成部分。它包括3α和12α位取代的羟基和支链末端的羧基。这些组成成分可对分子的亲水性产生影响并且疏水环戊烯并菲形成其中心。
Application
使用脱氧胆酸用作:
- 体外测定中的菌丝抑制化合物,以研究胃肠道中白色念珠菌的菌丝形态发生
- 一种用于估计细胞团块中毒素浓度的内部标准品
- 采用超高效液相色谱三重四极杆质谱联用技术定量在接受治疗的小鼠各种样品中定量测定BA的胆汁酸(BA)颗粒
Biochem/physiol Actions
脱氧胆酸的两亲性特性可显著有助于溶解、乳化和吸收体内的脂肪、维生素和胆固醇等。肠内脱氧胆酸含量高可通过诱导氧化应激和DNA损伤导致结肠直肠癌。它是一种致癌和促肿瘤因子。
Other Notes
用于β-肾上腺素能受体的增溶
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
E Nedivi et al.
The Journal of biological chemistry, 259(9), 5803-5808 (1984-05-10)
Agonist, but not antagonist, protects the beta-adrenergic receptor from inactivation during solubilization in deoxycholate. Protection is apparently due to locking of the agonist in the receptor, a high affinity interaction induced or stabilized by this detergent. The guanyl nucleotide-binding protein
Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates
Wang F, et al.
Carbohydrate Polymers, 84, 1192-1200 (2011)
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 30960-100G | 04061826676158 |
| 30960-25G | 04061826676172 |
