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35845

2′,7′-二氯荧光素二乙酸酯

Name: 2′,7′-二氯荧光素二乙酸酯
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥95% (HPLC)

别名:

DCFHDA, 双氯荧光黄乙酸乙酯

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关于此项目

经验公式（希尔记法）:

C₂₄H₁₄Cl₂O₇

化学文摘社编号:

2044-85-1

分子量:

485.27

UNSPSC Code:

12352108

NACRES:

NA.32

PubChem Substance ID:

57649438

MDL number:

MFCD00037501

Beilstein/REAXYS Number:

68488

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属性

Quality Level

100

description

suitable as a fluorogenic substrate for esterases

product line

BioReagent

assay

≥95% (HPLC)

form

powder or crystals

mol wt

485.27 g/mol

color

faint red, white to faint brown

mp

232-234 °C (lit.)

solubility

DMSO: soluble

fluorescence

λ_ex 504 nm; λ_em 524 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C4(OC(=O)c5ccccc45)c2cc1Cl

InChI

1S/C24H14Cl2O7/c1-11(27)30-21-9-19-15(7-17(21)25)24(14-6-4-3-5-13(14)23(29)33-24)16-8-18(26)22(31-12(2)28)10-20(16)32-19/h3-10H,1-2H3

InChI key

VQVUBYASAICPFU-UHFFFAOYSA-N

说明

General description

2′,7′-二氯荧光素二乙酸酯，也称为 DCFHDA 或 Dcfh-DA，是一种敏感的细胞可渗透氧化还原探针。亲脂性非荧光 Dcfh-DA 通过被动扩散和脱乙酰作用很容易穿过细胞膜。脱酰产物是一种对氧化剂敏感的 2′,7′-二氯荧光素（DCHF）。 DCHF 随后被氧化以形成高荧光 DCF，这是被测量的。

Application

2′,7′-二氯荧光素二乙酸酯主要用于检测活性氧（ROS）中间体并量化细胞中的过度 氧化应激 。

Dcfh-DA 用于定量测定，以测量纳米颗粒处理的细胞中的氧化应激。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

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货号	GTIN
35845-5G	04061831812824
35845-1G	04061835504411