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关于此项目
经验公式(希尔记法):
C15H22O5
化学文摘社编号:
分子量:
282.33
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
Quality Level
assay
98%
form
solid
optical activity
[α]20/D +76°, c = 0.5 in methanol
mp
156-157 °C (lit.)
antibiotic activity spectrum
parasites, viruses
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
mode of action
enzyme | inhibits
SMILES string
C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3OC4(C)CC[C@@H]1[C@@]23OO4
InChI
1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChI key
BLUAFEHZUWYNDE-NNWCWBAJSA-N
General description
青蒿素是从青蒿(Artemisia annua)中提取得到的。它具有抗癌、 抗原虫和抗病毒活性。青蒿素与脑干脑病有关。
Application
青蒿素已可用于:
- 药物敏感性测定
- 作为对毛状根所含青蒿素进行定量的标准品
- 通过3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑(MTT)测定来检测细胞活力
- 作为抗疟药,用于研究自噬相关(ATG)基因在恶性疟原虫( P. falciparum )无性和有性血液期的作用
Biochem/physiol Actions
青蒿素是一种倍半萜内酯,是一种高效的抗疟疾(恶性疟疾)药物。青蒿素也是一种能有效对抗血吸虫病的驱虫剂(寄生虫)。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections
Pillai DR, et al.
Malaria Journal, 11(1), 131-131 (2012)
Jürg Utzinger et al.
Current opinion in investigational drugs (London, England : 2000), 8(2), 105-116 (2007-03-03)
Schistosomiasis is a significant health issue caused by a blood fluke that affects more than 200 million individuals worldwide, over half of whom suffer from disease-associated symptoms. In areas of high burden, disease is mainly managed by controlling morbidity with
Deciphering genetic regulation of CD14 by SP1 through characterization of peripheral blood mononuclear transcriptome of P. faiciparum and P. vivax infected malaria patients
Chakraborty B, et al.
EBioMedicine, 37, 442-452 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 361593-100MG | 04061835541317 |