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44583

阿霉素 盐酸盐

suitable for fluorescence, 98.0-102.0% (HPLC)

别名:

DOX, 多柔比星® 盐酸盐, 羟基柔红霉素 盐酸盐

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关于此项目

经验公式（希尔记法）:
C27H29NO11 · HCl
化学文摘社编号:
25316-40-9
分子量:
579.98
UNSPSC Code:
51281818
NACRES:
NA.76
PubChem Substance ID:
57650234
EC Number:
246-818-3
Beilstein/REAXYS Number:
4229251
MDL number:
MFCD00077757
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biological source

synthetic

Quality Level

200

assay

98.0-102.0% (HPLC)

form

solid

color

orange to dark red

mp

216 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL, clear, orange to red, DMSO: soluble, THF: soluble, ethanol: soluble, methanol: soluble

fluorescence

λem 580-590 nm

suitability

suitable for fluorescence

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

Gene Information

human ... TOP2A(7153)

General description

化学结构：四环素

Application

阿霉素用于诱导细胞凋亡，并在 SK-N-MC 细胞中诱导心脏毒性。它用于抑制大分子的生物合成。

Biochem/physiol Actions

阿霉素是一种插入 DNA 并抑制大分子生物合成的抗肿瘤抗生素。由于拓扑异构酶 II 的抑制，DNA 复制被牵引。 它是逆转录酶和 RNA 聚合酶的抑制剂，是一种免疫抑制剂。

Packaging

无底玻璃瓶。内含物装在锥底内插管中。

Other Notes

保存于密闭容器内，置于干燥通风处。

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD1159V
0000036131
079M4767V
079M4766V
079M4765V

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Inhibition of Nucleic Acid Synthesis by Antibiotics

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货号GTIN
44583-10MG04061832284118
44583-1MG04061832284132
44583-50MG04061835541379