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Merck
CN

44707

阿维A酸

≥98.0% (HPLC)

别名:

9-(4-甲氧基-2,3,6-三甲基苯基)-3,7-二甲基壬酸-2,4,6,8-四烯酸

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关于此项目

经验公式(希尔记法):
C21H26O3
化学文摘社编号:
分子量:
326.43
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
259-474-4
MDL number:
Assay:
≥98.0% (HPLC)
Form:
powder
Quality level:
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Quality Level

assay

≥98.0% (HPLC)

form

powder

SMILES string

COc1cc(C)c(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)c(C)c1C

InChI

1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+

InChI key

IHUNBGSDBOWDMA-AQFIFDHZSA-N

Application

阿维 A 是一种可与核受体结合并调节基因表达的类视黄醇,是通过 CD95 信号通路的 α-分泌酶 ADAM10 基因表达和凋亡诱导剂的有效激活剂。 阿维 A 是一种用于治疗严重银屑病的全身性维甲酸类药物。

Biochem/physiol Actions

合成维甲酸,是依曲甲酸酯的代谢物。 优先与细胞视黄酸结合蛋白(CRABP) 结合。


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Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容


David Holthoewer et al.
Neuro-degenerative diseases, 10(1-4), 224-228 (2012-02-04)
ADAM10 (a disintegrin and metalloproteinase 10) has been demonstrated to act as the main physiological α-secretase. Enzymatic activity of the α-secretase on the one hand prevents the formation of toxic Aβ peptides and on the other hand promotes the secretion
Justin D Lutz et al.
Biochemical pharmacology, 77(2), 258-268 (2008-11-11)
Retinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26 family are thought to be responsible for the elimination
Systemic retinoid therapy for chemoprevention of nonmelanoma skin cancer in a patient treated with vemurafenib.
Rachael Anforth et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(19), e165-e167 (2012-06-06)



全球贸易项目编号

货号GTIN
44707-25MG04061832404387
44707-100MG04061832404370