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56496

钙黄绿素-AM

Name: 钙黄绿素-AM
Brand: SIGMA

Small Package (20 X 50 μg ), ≥90.0% (HPLC)

别名:

荧光素氨羧络合试剂, 钙黄绿素四乙酰氧基 O,O′-二乙酸酯, Calcein O,O′-diacetate tetrakis(acetoxymethyl) ester

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关于此项目

经验公式（希尔记法）:

C₄₆H₄₆N₂O₂₃

化学文摘社编号:

148504-34-1

分子量:

994.86

NACRES:

NA.32

PubChem Substance ID:

329758218

UNSPSC Code:

12171500

MDL number:

MFCD05861516

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属性

Quality Level

100

assay

≥90.0% (HPLC)

fluorescence

λ_ex 496 nm; λ_em 516 nm±5 nm in 0.1 M Tris pH 8.0, esterase; Ca²⁺

storage temp.

−20°C

SMILES string

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)Cc1c(OC(C)=O)ccc2c1Oc3c(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OC(C)=O)ccc3C24OC(=O)c5ccccc45

InChI

1S/C46H46N2O23/c1-25(49)60-21-64-39(55)17-47(18-40(56)65-22-61-26(2)50)15-32-37(68-29(5)53)13-11-35-43(32)70-44-33(16-48(19-41(57)66-23-62-27(3)51)20-42(58)67-24-63-28(4)52)38(69-30(6)54)14-12-36(44)46(35)34-10-8-7-9-31(34)45(59)71-46/h7-14H,15-24H2,1-6H3

InChI key

XKFSBWQWNMZWFA-UHFFFAOYSA-N

说明

General description

钙黄绿素-AM，也称钙黄绿素-乙酰甲酯，是一种不发射荧光的分子，在细胞内酯酶的作用下会转化为阴离子荧光形式。在实验过程中它可以使黏附细胞连续成像。钙黄绿素-AM是一种必不可少的染料，可在保持细胞膜完整的情况下将钙黄绿素引入活细胞。钙黄绿素-AM中发射荧光的部分位于细胞间隙，在以酯酶依赖型关系在细胞中捕获，之后显示出细胞中的细胞毒性活性。

Application

钙黄绿素-AM是一种细胞活力染料，也可作为多药外排性转运体（multidrug efflux transporter）的中性底物。在癌症研究中，它可用作多药耐药蛋白MRP的中性底物。用于测定人红细胞活力和老化的荧光测试法是以钙黄绿素-AM为探针。

钙黄绿素的非荧光细胞渗透衍生物，水解后发出荧光。用作多药耐药蛋白MRP的中性底物；用于肿瘤研究。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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全球贸易项目编号

货号	GTIN
56496-20X50UG	04061826687901