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76904

维库溴铵

Name: 维库溴铵
Brand: SIGMA

别名:

1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-piperidinium bromide

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关于此项目

经验公式（希尔记法）:

C₃₄H₅₇BrN₂O₄

化学文摘社编号:

50700-72-6

分子量:

637.73

UNSPSC Code:

51152000

NACRES:

NA.77

PubChem Substance ID:

329767429

EC Number:

256-723-9

Beilstein/REAXYS Number:

4837308

MDL number:

MFCD00867762

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属性

biological source

synthetic

Quality Level

100

assay

≥97.0% (TLC)

form

powder or crystals

functional group

carboxylic acid

SMILES string

[Br-].CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@@H]([C@@H]4OC(C)=O)[N+]5(C)CCCCC5)[C@@]2(C)C[C@@H]1N6CCCCC6

InChI

1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1

InChI key

VEPSYABRBFXYIB-PWXDFCLTSA-M

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

说明

Biochem/physiol Actions

Vecuronium Bromide is an aminosteroidal neuromuscular blocking agent. It relaxes the skeletal muscle and decreases oxygen consumption during surgery. It competes with acetylcholine and bind to cholinergic receptors at neuromuscular junctions.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Magnesium sulfate enhances non-depolarizing muscle relaxant vecuronium action at adult muscle-type nicotinic acetylcholine receptor in vitro.

Hong Wang et al.

Acta pharmacologica Sinica, 32(12), 1454-1459 (2011-10-12)

To investigate the effect of magnesium sulfate and its interaction with the non-depolarizing muscle relaxant vecuronium at adult muscle-type acetylcholine receptors in vitro. Adult muscle-type acetylcholine receptors were expressed in HEK293 cells. Drug-containing solution was applied via a gravity-driven perfusion

Quantitative analysis of the aminosteroidal non-depolarizing neuromuscular blocking agent vecuronium by LC-ESI-MS: A Postmortem Investigation.

Shawn P Vorce et al.

Journal of analytical toxicology, 32(6), 422-427 (2008-07-26)

The apparent recreational use of an aminosteroidal non-depolarizing neuromuscular blocking agent, vecuronium, is reported in this postmortem investigation. A quantitative method for the analysis of vecuronium and its active metabolite, 3-desacetylvecuronium, in blood and tissue samples was developed using liquid

Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle.

Hong WANG et al.

Acta pharmacologica Sinica, 31(12), 1541-1546 (2010-11-26)

to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated

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全球贸易项目编号

货号	GTIN
15469-1G	04061826100967
76904-10MG	04061832924878