83702
罗丹明123
BioReagent, suitable for fluorescence, ≥85% (HPLC)
别名:
2-(6-氨基-3-亚氨基-3H-呫吨-9-基)苯甲酸甲酯
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关于此项目
线性分子式:
C21H17ClN2O3
化学文摘社编号:
分子量:
380.82
UNSPSC Code:
12352116
NACRES:
NA.32
PubChem Substance ID:
EC Number:
263-687-8
Beilstein/REAXYS Number:
6030951
MDL number:
product line
BioReagent
Quality Level
assay
≥85% (HPLC)
form
powder
impurities
≤10% water
solubility
ethanol: 20 mg/mL, clear, red
suitability
in accordance for fluorescence, suitable for fluorescence
SMILES string
Cl[H].COC(=O)c1ccccc1C2=C3C=CC(=N)C=C3Oc4cc(N)ccc24
InChI
1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
InChI key
MYFATKRONKHHQL-UHFFFAOYSA-N
General description
罗丹明123是荧光染料。
Application
罗丹明123用于：
- 作为P-糖蛋白（P-gp）的底物，可在荧光积累测定中读出功能性转运体活性
- 标记细胞，通过流式细胞术估计P-gp的表达情况
- 在转运研究中，添加至顶端到基底外侧（AB-转运）或基底外侧到顶端（BA-转运）
- 检测线粒体膜电位（ΔΨm）
Biochem/physiol Actions
罗丹明123通常作为官能报告物，报告流式细胞术中的P-糖蛋白（P-gp）。
最常用于流式细胞术的荧光染料，可用作Pgp的功能性报告分子。在癌症治疗中，MDR蛋白的功能测定是比MDR蛋白表达水平更好的预后指标。Rh 123可用于多参数分析而无荧光干扰，可与常用蛋白质标记染料组合使用，如PE-Cy5和AMCA（7-氨基-4-甲基香豆素-3-乙酸）。近期报道表明，Rh123也可能是MRP1的底物。
Other Notes
上活体线粒体特异性染料
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
Evidence of apoptosis in Raillietina echinobothrida induced by methanolic extracts of three traditional medicinal plants of Northeast India
Giri BR, et al.
Experimental Parasitology, 134(4), 466-473 (2013)
L Benel et al.
Basic and applied histochemistry, 33(2), 71-80 (1989-01-01)
The use of the supravital mitochondrial-specific dye Rhodamine 123 (Rh 123) in combination with flow cytometry permits the monitoring of the changes in the mitochondrial transmembrane potential, reflecting the overall mitochondrial activity of the living cell. While this probe appears
Fumihiko Takeuchi et al.
PloS one, 10(7), e0132030-e0132030 (2015-07-07)
The Myxozoa are oligo-cellular parasites with alternate hosts--fish and annelid worms--and some myxozoan species harm farmed fish. The phylum Myxozoa, comprising 2,100 species, was difficult to position in the tree of life, due to its fast evolutionary rate. Recent phylogenomic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 83702-50MG | 04061833005798 |
| 83702-10MG | 04061833005781 |