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Merck
CN

90790

L-α-羟基戊二酸 二钠盐

≥98.0% (GC)

别名:

(S)-2-羟基戊二酸 二钠盐, (S)-2-羟基戊二酸二钠

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关于此项目

线性分子式:
C5H6O5Na2
化学文摘社编号:
分子量:
192.08
UNSPSC Code:
12352106
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5318042
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Quality Level

assay

≥98.0% (GC)

form

powder or crystals

optical activity

[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH

impurities

≤6.0% water

relevant disease(s)

cancer

storage temp.

2-8°C

SMILES string

[O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

InChI key

DZHFTEDSQFPDPP-QTNFYWBSSA-L

General description

产气消化球菌(Peptococcus aerogenes)的无细胞提取物以NAD依赖性方式将谷氨酸代谢为α-羟基戊二酸。它是细菌的乙醛酸代谢过程中形成的中间体。

Application

L-α-羟基戊二酸二钠盐适用于收集缓冲液,用于提高缺氧诱导因子-1 α(HIF-1 α)的回收率,HIF-1 α是人肿瘤的缺氧标志物。它也适用于放射性标记的5mC-5hmC转化试验,以研究2-HG对甲基羟化酶TET家族的影响。

Biochem/physiol Actions

罕见的L-2-HG脱氢酶缺陷可引起L-α-羟基戊二酸积累,导致代谢紊乱L-2-羟基戊二酸尿症(L-2HGA)。L-2HGA与神经元缺陷、脑白质营养不良以及脑肿瘤风险增加有关。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.


The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.
W M Johnson et al.
Canadian journal of biochemistry, 47(12), 1103-1107 (1969-12-01)
Hugh Colvin et al.
Scientific reports, 6, 36289-36289 (2016-11-09)
Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH)
Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.
A S Bleiweis et al.
Analytical biochemistry, 20(2), 335-338 (1967-08-01)



全球贸易项目编号

货号GTIN
90790-10MG04061833381649
90790-50MG04061833381656