I6634
胰岛素 来源于牛胰腺
powder, BioReagent, suitable for cell culture
别名:
Bovine insulin, Cell culture grade insulin
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关于此项目
经验公式（希尔记法）:
C254H377N65O75S6
化学文摘社编号:
分子量:
5733.49
UNSPSC Code:
12352209
NACRES:
NA.77
EC Number:
234-291-2
MDL number:
Biological source:
bovine
Form:
powder
biological source
bovine
Quality Level
product line
BioReagent
form
powder
potency
≥25 USP units per mg
technique(s)
cell culture | mammalian: suitable, single cell analysis: suitable
solubility
acetic acid: 2 mg/mL (pH: 2-3), hydrochloric acid: 2 mg/mL (pH: 2-3)
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
InChI key
IXIBAKNTJSCKJM-BUBXBXGNSA-N
Gene Information
cow ... INS(280829)
Application
在许多哺乳动物细胞培养系统中胰岛素被用作生长因子。
- 来自牛胰腺的胰岛素已被用于将 MSC（间充质干细胞）分化为脂肪细胞。
- 它已被用于培养各种细胞。
- 它还被用于研究胰岛素介导的 HMGCS2（3-羟基-3-甲基戊二酰辅酶 A （HMG-辅酶A） 合酶）基因的抑制。
Biochem/physiol Actions
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。
Physical form
粉末-0 °C；储备液可在2-8 °C稳定1年
Preparation Note
胰岛素在中性 pH 下溶解度低。它可以 2 mg/ml 的浓度溶解在 pH 2-3 的稀乙酸或盐酸中。
Other Notes
InChI: 1S/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-167(94-139-52-60-145(324)61-53-139)226(365)282-153(68-75-186(258)328)217(356)289-160(86-121(4)5)221(360)284-157(73-80-198(342)343)219(358)301-173(100-189(261)331)233(372)297-169(96-141-56-64-147(326)65-57-141)229(368)308-182(241(380)303-175(253(393)394)102-191(263)333)115-398-396-113-180(212(351)270-106-193(335)277-152(71-78-196(338)339)215(354)280-150(50-41-83-268-254(264)265)210(349)269-107-194(336)278-165(92-137-45-35-31-36-46-137)225(364)296-166(93-138-47-37-32-38-48-138)228(367)298-170(97-142-58-66-148(327)67-59-142)236(375)318-206(135(28)323)251(390)319-84-42-51-185(319)244(383)285-151(49-39-40-82-255)213(352)276-134(27)252(391)392)310-248(387)202(128(18)19)315-234(373)163(89-124(10)11)291-227(366)168(95-140-54-62-146(325)63-55-140)295-222(361)159(85-120(2)3)288-207(346)132(25)274-214(353)156(72-79-197(340)341)286-245(384)201(127(16)17)314-235(374)164(90-125(12)13)292-231(370)172(99-144-105-267-119-273-144)300-237(376)176(109-320)279-195(337)108-271-211(350)179(112-395-397-114-181(309-243(183)382)240(379)275-133(26)208(347)304-178(111-322)239(378)316-203(129(20)21)249(388)311-184)306-224(363)162(88-123(8)9)290-230(369)171(98-143-104-266-118-272-143)299-218(357)154(69-76-187(259)329)283-232(371)174(101-190(262)332)302-247(386)200(126(14)15)313-209(348)149(257)91-136-43-33-30-34-44-136/h30-38,43-48,52-67,104-105,118-135,149-185,200-206,320-327H,29,39-42,49-51,68-103,106-117,255-257H2,1-28H3,(H2,258,328)(H2,259,329)(H2,260,330)(H2,261,331)(H2,262,332)(H2,263,333)(H,266,272)(H,267,273)(H,269,349)(H,270,351)(H,271,350)(H,274,353)(H,275,379)(H,276,352)(H,277,335)(H,278,336)(H,279,337)(H,280,354)(H,281,355)(H,282,365)(H,283,371)(H,284,360)(H,285,383)(H,286,384)(H,287,385)(H,288,346)(H,289,356)(H,290,369)(H,291,366)(H,292,370)(H,293,377)(H,294,362)(H,295,361)(H,296,364)(H,297,372)(H,298,367)(H,299,357)(H,300,376)(H,301,358)(H,302,386)(H,303,380)(H,304,347)(H,305,381)(H,306,363)(H,307,359)(H,308,368)(H,309,382)(H,310,387)(H,311,388)(H,312,334)(H,313,348)(H,314,374)(H,315,373)(H,316,378)(H,317,389)(H,318,375)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,391,392)(H,393,394)(H4,264,265,268)/t131-,132-,133-,134-,135+,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,200-,201-,202-,203-,204-,205-,206-/m0/s1
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
兴奋剂肽类激素
低风险生物材料
此项目有
相关内容
Instructions
Boah Lee et al.
PloS one, 12(8), e0183569-e0183569 (2017-08-29)
Pancreatic islets can adapt to oscillatory glucose to produce synchronous insulin pulses. Can islets adapt to other oscillatory stimuli, specifically insulin? To answer this question, we stimulated islets with pulses of exogenous insulin and measured their Ca2+ oscillations. We observed
Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1.
Nadal A et al.
The Biochemical Journal, 366, 289-289 (2002)
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
Peng DJ et al.
Journal of Immunology, 186, 5638-5638 (2011)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I6634-250MG | 04061833857847 |
| I6634-100MG | 04061833857823 |
| I6634-1G | 04061833857830 |
| I6634-25MG | 04061833857854 |
| I6634-500MG | 04061833857861 |
| I6634-50MG | 04061835518975 |