L5543
脂多糖 来源于大肠杆菌 026:B6
Ready Made solution, 1 mg/mL, 0.2 μm filtered
别名:
LPS
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关于此项目
biological source
Escherichia coli (O26:B6)
Quality Level
sterility
0.2 μm filtered
form
aqueous solution
concentration
1 mg/mL
color
colorless to faint yellow
solubility
water: soluble
shipped in
wet ice
storage temp.
2-8°C
General description
本品为 0.2 um 过滤水溶液，含 1 mg/mL 来自大肠杆菌血清型 O26：B6 的脂多糖 (LPS)。这种 LPS 血清型已被用于感染性休克研究。
Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
Preparation Note
用于制备溶液的 LPS 经过苯酚提取和凝胶过滤层析纯化。通过苯酚提取制备的脂多糖含有高达 60% 的 RNA 和少于 1% 的蛋白质。随后通过凝胶过滤色谱法进行纯化，可去除苯酚提取的 LPS 中存在的大部分蛋白质，但留下的产物仍含有 10-20% 的核酸。采用离子交换色谱法进一步纯化，得到含 <1% 蛋白质和 <1% RNA 的 LPS 产品。
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5543-2ML | 04061833958254 |