biological source
Salmonella enterica (Serotype typhimurium)
Quality Level
form
lyophilized powder
purified by
phenol extraction
impurities
<3% Protein (Lowry)
color
white to faint yellow
solubility
water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
General description
本品为从鼠伤寒沙门菌中提取的苯酚。来源菌株为 ATCC 7823。该 LPS 已被用于诱导大鼠和豚鼠的 NOS。
Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，Toll样受体 4是Toll样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖 (LPS) 定位于膜的外层，在无荚膜的菌株中暴露于细胞表面。它们有助于外膜的完整性，并保护细胞免受胆盐和亲脂性抗生素的操作。
Preparation Note
本品可溶于水 (5 mg/mL) 或细胞培养基 (1 mg/mL)，得到淡黄色浑浊溶液。涡旋并加热至 70-80 oC 后，在盐水中获得了更浓缩但仍浑浊的溶液 (20 mg/mL)。脂多糖是在每种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中观察到浑浊溶液。有机溶剂不能提供更清晰的溶液。甲醇产生浑浊的带有悬浮物的混悬液，而水产生均匀的浑浊溶液。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
C Marcq et al.
Poultry science, 90(1), 59-67 (2010-12-24)
In this study, Salmonella enterica serovar Typhimurium challenge models were tested to identify the best conditions under which to perform the experimental infection of 3-wk-old broilers. Such a model would be useful to study the efficiency of therapeutic treatments that
Alejandro Carrillo-Jimenez et al.
Frontiers in cellular neuroscience, 12, 313-313 (2018-10-10)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer's disease (AD). The use of primary microglial cell cultures has proved to be a valuable tool to study microglial biology under various
Li Liang et al.
Scientific reports, 3, 1043-1043 (2013-01-11)
Current serological diagnostic assays for typhoid fever are based on detecting antibodies against Salmonella LPS or flagellum, resulting in a high false-positive rate. Here we used a protein microarray containing 2,724 Salmonella enterica serovar Typhi antigens (>63% of proteome) and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L6511-25MG | 04061833275146 |
| L6511-100MG | 04061833958858 |
| L6511-10MG | 04061833275139 |