产品名称
单克隆抗 β-微管蛋白 III 小鼠抗, clone SDL.3D10, ascites fluid
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
SDL.3D10, monoclonal
contains
15 mM sodium azide
species reactivity
bovine, rat, human, boar
packaging
antibody small pack of 25 μL
enhanced validation
knockout
Learn more about Antibody Enhanced Validation
technique(s)
indirect ELISA: suitable, western blot: 1:400 using a rat brain extract
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUBB3(10381)
rat ... Tubb3(246118)
General description
单克隆抗-μ微管蛋白同种型III(小鼠IgG2b同种型)来源于通过小鼠骨髓瘤细胞与BALB/c小鼠脾细胞融合产生的SDL.3D10杂交瘤。
微管蛋白 β 3 III类(TUBB3)也称 β-微管蛋白III,由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。
Immunogen
相应的人 β 羧基端序列的合成肽-与 BSA 偶联的微管蛋白同型 III
Application
它还用于免疫荧光分析。
小鼠源抗β-微管蛋白 III 单克隆抗体可用于以下研究:
- 免疫细胞化学。
- 流式细胞术。
- 免疫印迹。
Biochem/physiol Actions
微管蛋白 β 3 III类(TUBB3)在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化(CFEOM3)和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中,TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长;因此,它是开发抗肿瘤药物的潜在靶标。
该抗体特异性识别位于 β-微管蛋白。未观察到与其他微管蛋白同种型的交叉反应。当用微管蛋白和 tau 或 MAP2 重组时,抗体可刺激微管装配。
Other Notes
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明,否则我们的产品仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动物来源生物产品
常规特殊物品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T8660-.2ML | 04061837379536 |
| T8660-100UL | 04061837379543 |