登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式(希尔记法):
C34H40N2O18
化学文摘社编号:
分子量:
764.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
7458534
产品名称
BAPTA-AM, ≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccccc1OCCOc2ccccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key
YJIYWYAMZFVECX-UHFFFAOYSA-N
General description
BAPTA-AM抑制自由基介导的毒性,增强非神经细胞中细胞凋亡,保护神经细胞免受缺血性损伤。它调节离子通道,阻止神经Ca2+-激活K+通道电流。BAPTA-AM维持细胞内Ca2+动态平衡。
Application
BAPTA-AM用于:
- 降低剪切后半胱氨酸蛋白酶-3升高水平
- 阻止细胞死亡,抑制ROS(活性氧化簇)产物,抑制半胱氨酸蛋白酶-8活性。
- 排除细胞内Ca2+ ([Ca2+]i) 浓度变化对癫痫诱导影响
- 消除6-羟多巴胺(6-OHDA)诱导的[Ca2+]i增量水平
Biochem/physiol Actions
细胞内Ca2+储存选择性螯合剂。
Other Notes
BAPTA膜透过形式。
Still not finding the right product?
Explore all of our products under BAPTA-AM
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
Sigma-Aldrich presents a Biofiles on Detect, Visualize and Quantify Single Post-Translational Modifications
BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures
Wie MB, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 25(8), 1641-1659 (2001)
The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells
Tang Q, et al.
Biochemical Pharmacology, 74(11), 1596-1607 (2007)
M-calpain activation facilitates seizure induced KCC2 down regulation
Wan L, et al.
Frontiers in Molecular Neuroscience, 11, 287-287 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1076-25MG | 04061833334867 |