A165
Rp-腺苷 3′，5′-环状单硫代磷酸酯 三乙铵盐
≥98% (HPLC), cAMP antagonist, powder
别名:
Rp-cAMPS 三乙铵盐, Rp-环状 3′，5′-氢硫代磷酸酯腺苷 三乙铵盐
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关于此项目
经验公式（希尔记法）:
C10H11N5O5PS · C6H16N
化学文摘社编号:
分子量:
446.46
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Rp-腺苷 3′，5′-环状单硫代磷酸酯 三乙铵盐, powder, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL
λmax
258 nm
storage temp.
−20°C
SMILES string
CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=S)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21?;/m1./s1
InChI key
OXIPZMKSNMRTIV-NVGWRVNNSA-N
Application
Rp-腺苷-3′，5′-环一硫代磷酸三乙酯铵盐已被用作cAMP的拮抗剂，以阻断cAMP-PKA信号通路。
Biochem/physiol Actions
Rp-腺苷-3′，5′-环一硫代磷酸三乙酯铵盐能够抑制蛋白激酶A（PKA）。
腺苷-3′，5′-环状单硫代磷酸酯 Rp-非对映异构体。cAMP（cAMP 依赖性蛋白激酶I 和 II）激活作用的特异性膜渗透性抑制剂；对环核苷酸磷酸二酯酶具有抗性；在许多系统中阻断 cAMP 介导的作用。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Disclaimer
非常吸湿。储存于干燥处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Shaomin Peng et al.
Investigative ophthalmology & visual science, 51(6), 3216-3225 (2010-01-01)
Bevacizumab and ranibizumab are currently used to treat age-related macular degeneration by neutralizing vascular endothelial growth factor (VEGF). In this study, the potential side effects on the outer blood-retinal barrier were examined. Human fetal RPE (hfRPE) cells were used because
J D Rothermel et al.
The Journal of biological chemistry, 259(13), 8151-8155 (1984-07-10)
The ability of the Rp diastereomer of adenosine cyclic 3',5'-phosphorothioate (Rp cAMPS) to inhibit glucagon-induced glycogenolysis was studied in hepatocytes isolated from fed rats. Preincubation of the cells for 20 min with progressively higher concentrations of Rp cAMPS followed by
L Y Wang et al.
Science (New York, N.Y.), 253(5024), 1132-1135 (1991-09-06)
In the mammalian central nervous system, receptors for excitatory amino acid neurotransmitters such as the alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA)-kainate receptor mediate a large fraction of excitatory transmission. Currents induced by activation of the AMPA-kainate receptor were potentiated by agents that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A165-1MG | 04061833342626 |
| A165-10MG | 04061832895598 |
| A165-5MG | 04061832895604 |