A1752
腺苷-5′-单磷酸 钠盐
≥99%, from yeast, powder
别名:
5′-腺苷酸, A-5′-P, AMP
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关于此项目
经验公式（希尔记法）:
C10H14N5O7P · xNa+ · yH2O
化学文摘社编号:
分子量:
347.22 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
Assay:
≥99%
Biological source:
yeast
Form:
powder
Solubility:
H2O: soluble
Storage temp.:
−20°C
产品名称
腺苷-5′-单磷酸 钠盐, from yeast, ≥99%
biological source
yeast
Quality Level
assay
≥99%
form
powder
solubility
H2O: soluble
storage temp.
−20°C
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.
Application
5′-单磷酸腺苷钠盐已用于：
- 作为再激活培养基组分，再激活从附睾尾提取的小鼠精子，进行精子动力研究
- 作为通过可逆交换实现放大信号(SABRE)方法的底物，建立生物相容性SABRE超极化
- 作为小麦和黑曲霉Aspergillus niger植酸酶检测中的底物
- 用于荧光素酶检测，监测S1S2细胞内的α-突触核蛋白低聚反应
- 研究其对心脏骤停(CA)和复苏大鼠模型中治疗诱导性低温和神经损伤的影响
Biochem/physiol Actions
5′-单磷酸腺苷(5′-AMP)可用于增强肉和禽肉汤的鲜味。还可作为食品添加剂满足特别的营养需求。5′-AMP是AMP活化蛋白激酶(AMPK)这类蛋白激酶的激活剂。 AMP可协同肌苷单磷酸(IMP)介导骨骼肌肌动球蛋白分解为肌动蛋白和肌球蛋白。因此，这两种因子可能有参与肌肉解僵。
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
实验方案
在测定5′-核苷酸酶活性时，本操作流程使用5′-单磷酸腺苷和一种显色试剂生成的标准曲线而对释放的磷的微摩尔数进行测定。
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
To measure 5′-nucleotidase activity, this procedure uses adenosine 5’-monophosphate and a color reagent to create a standard curve for determining the micromoles of phosphorus liberated.
Yugo Tsuchiya et al.
Bioscience reports, 32(2), 197-213 (2011-08-20)
In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and
Alexey S Kiryutin et al.
Magnetic resonance in chemistry : MRC (2021-06-05)
Signal amplification by reversible exchange (SABRE) is a popular method for generating strong signal enhancements in nuclear magnetic resonance (NMR). In SABRE experiments, the source of polarization is provided by the nonthermal spin order of parahydrogen (pH2 , the H2
Mikkel G Terp et al.
Molecular oncology, 15(12), 3299-3316 (2021-06-25)
RAS-MAPK signaling promotes immune evasion and cancer cell survival, and MAPK inhibitors (MAPKis) are frequently used as cancer therapies. Despite progress elucidating the direct effects of MAPKi on immune cells, their indirect effect on the tumor microenvironment (TME) through changes
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1752-1G | 04061833342930 |
| A1752-100MG | 04061831168426 |
| A1752-25G | 04061833342947 |
| A1752-5G | 04061833342954 |