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A2129

γ-氨基丁酸

≥99% (TLC), powder or crystals, inhibitory neurotransmitter

别名:

γ-氨酪酸, GABA, Gammalon, ]γ-氨酪酸, 3-羧丙胺, 4-氨基丁酸, 哌啶酸, 氨酪酸

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关于此项目

线性分子式:
NH2(CH2)3COOH
化学文摘社编号:
56-12-2
分子量:
103.12
NACRES:
NA.32
PubChem Substance ID:
24278167
UNSPSC Code:
12352106
EC Number:
200-258-6
MDL number:
MFCD00008226
Beilstein/REAXYS Number:
906818
Assay:
≥99%
Form:
powder or crystals
Quality level:
200
Storage condition:
(Tightly closed. Dry.)
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产品名称

γ-氨基丁酸, ≥99%

Quality Level

200

assay

≥99%

form

powder or crystals

storage condition

(Tightly closed. Dry.)

color

colorless

mp

195 °C (dec.) (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)

General description

γ-氨基丁酸 (GABA) 是一种非氨基蛋白质，存在于植物、动物和微生物中。GABA已应用于制药和食品工业，作为奶酪、烧酒、金白龙茶和精油成分。
研究领域：神经科学

Application

γ-氨基丁酸(GABA)用于：
  • 制备GABA-BSA（牛血清蛋白）-GA（戊二醛）复合物，用于GABA免疫染色对照。
  • 核磁共振(MRS)高分子抑制检测。
  • GABA肠内给药，降低管腔内液体分泌

Biochem/physiol Actions

GABA（γ-氨基丁酸）是一种氨基酸，作为中枢神经系统中的抑制性神经递质，在某些外周组织中也可用作神经调节剂。其可与GABAA受体结合，抑制信号接收神经元活性。GABAA受体能够在神经细胞细胞膜形成通道。一旦和GABA结合，受体被激活，允许带负电的分子，比如氯离子通过通道，进入细胞。这导致细胞兴奋性降低。
GABA 能神经元参与肌肉松弛、抗焦虑治疗、镇静和麻醉。GABA 还可影响心率和血压。
GABA可以改善大脑中的血浆浓度、生长激素和蛋白质合成。它还在降低人体血压方面发挥作用。GABA 是一种有效的降压药、利尿剂和抗糖尿病 药。它还可调节血脂水平和疼痛感。
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCD6141
BCCD3000
BCCC4017
BCBX6886
BCBV0838

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A2129-500G04061833001868
A2129-100G04061835551101
A2129-10G04061835551118
A2129-1KG04061833349601
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