A2169
3′-叠氮-3′-脱氧胸苷
≥98% (HPLC), powder, reverse transcriptase inhibitor
别名:
AZT, ZDV, 叠氮胸苷, 齐多夫定
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关于此项目
经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
分子量:
267.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3595791
产品名称
3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
mp
113-115 °C (lit.)
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI
1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI key
HBOMLICNUCNMMY-XLPZGREQSA-N
Gene Information
human ... HIVE1(3095)
mouse ... Slc29a1(63959)
Application
3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。
Biochem/physiol Actions
叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。
Features and Benefits
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
商品
业内研究了CRISPR基因组编辑背景下的HDR调控，发现各种细胞类型中增强CRISPR介导的HDR效率的小分子。
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Discover Bioactive Small Molecules for ADME/Tox
Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransduction
Geering B, et al.
Journal of Immunological Methods, 373(1-2), 209-218 (2011)
Zahidul Khan et al.
Neuro-oncology, 12(6), 549-558 (2010-02-16)
The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered
In vitro activities of nucleoside analog antiviral agents against salmonellae.
Sperber S J, et al.
Antimicrobial Agents and Chemotherapy, 37(1), 106-110 (1993)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A2169-250MG | 04061833349687 |
| A2169-25MG | 04061833349694 |
| A2169-100MG | 04061833349670 |
| A2169-1G | 04061826221044 |