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A255

A-77636 hydrochloride hydrate

Name: A-77636 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), solid

别名:

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₇NO₃ · HCl · xH₂O

化学文摘社编号:

145307-34-2

分子量:

365.89 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277883

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated, protect from light

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light

color

white to off-white

solubility

H₂O: >10 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChI key

KNACNUUSUYTFDY-LIWDBWMRSA-N

Gene Information

human ... DRD1(1812)

说明

Biochem/physiol Actions

Potent, orally active D₁ dopamine receptor agonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under exclusive license from Abbott Laboratories.

Disclaimer

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of dopamine on NaCl transport in the medullary thick ascending limb of the rat.

J Grider et al.

European journal of pharmacology, 342(2-3), 281-284 (1998-04-21)

The aim of the present study was to determine whether dopamine affects NaCl reabsorption in the medullary thick ascending limb of the loop of Henle. Basolateral dopamine (10(-6) M) significantly inhibited Cl- reabsorption in the in vitro microperfused rat medullary

The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration.

L A Smith et al.

Journal of neural transmission (Vienna, Austria : 1996), 109(2), 123-140 (2002-06-22)

The potent and long acting D-1 receptor agonist, A-77636 reverses motor deficits in MPTP treated common marmosets following subcutaneous or oral administration. We now explore the effects of acute versus repeated administration of A-77636 and the relative roles of D-1

Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636.

C W Lin et al.

The Journal of pharmacology and experimental therapeutics, 276(3), 1022-1029 (1996-03-01)

A-77636 is a dopamine (DA) D1 receptor-selective agonist that was previously shown to elicit beneficial responses in animal models of Parkinson's disease (PD) (Kebabian et al.: Eur. J. Pharmacol. 229: 203, 1992). However, A-77636 is of limited potential for PD

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全球贸易项目编号

货号	GTIN
A255-100MG	04061832079134
A255-10MG	04061832079141