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Merck
CN

A3886

Aprotinin

powder

别名:

BPTI, 抑肽酶, 牛胰胰蛋白酶抑制剂, 胰蛋白酶抑制剂(碱性)

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关于此项目

经验公式(希尔记法):
C284H432N84O79S7
化学文摘社编号:
分子量:
6511.44
UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
232-994-9
MDL number:
eCl@ss:
32190102
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产品名称

抑肽酶 来源于牛肺,

biological source

bovine lung

Quality Level

form

powder

mol wt

~6,500

packaging

vial of 15 mg

solubility

glycerol: 3 mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)

UniProt accession no.

storage temp.

−20°C

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Gene Information

cow ... PTI(404172)

Application

抑肽酶被大量用作胰蛋白酶抑制剂。
Gel filtration molecular weight marker

Biochem/physiol Actions

抑肽酶是一种竞争性丝氨酸蛋白酶抑制剂,可与酶的活性位点组成稳定的复合酶并同时对其进行封闭。 这种结合是可逆的,而且绝大多数抑肽酶-蛋白酶复合物可在极端的pH >10 or < 3水平时发生解离。 从结构上来说,抑肽酶是一种来自牛肺的单体球状蛋白,由58个氨基酸组成并排列在具有三个交联二硫键的单个多肽链中。

Other Notes

一个胰蛋白酶抑制剂单位(TIU)可将两个胰蛋白酶单位的活性降低50%,而其中一个胰蛋白酶单位在pH 7.8和25℃下可每分钟水解1.0 μ摩尔的N-α-苯甲酰基-DL-精氨酸对硝基苯胺。另一种常用的单位是KIU,而1 TIU = 1,300 KIU。


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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
动植物源性产品

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Alexander F L Later et al.
The Journal of thoracic and cardiovascular surgery, 145(6), 1611-1616 (2013-01-22)
Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved. Whole-blood
Halil Kaya et al.
JPMA. The Journal of the Pakistan Medical Association, 63(1), 32-37 (2013-07-20)
To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised
Andrew T Fenley et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20006-20011 (2012-11-15)
Molecular dynamics simulations of unprecedented duration now can provide new insights into biomolecular mechanisms. Analysis of a 1-ms molecular dynamics simulation of the small protein bovine pancreatic trypsin inhibitor reveals that its main conformations have different thermodynamic profiles and that



全球贸易项目编号

货号GTIN
A3886-1VL04061833368190