A4660
6-硫代鸟嘌呤
Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma
别名:
2-氨基-6-巯嘌呤, 2-氨基-6巯基嘌呤
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关于此项目
经验公式（希尔记法）:
C5H5N5S
化学文摘社编号:
分子量:
167.19
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
205-827-2
Beilstein/REAXYS Number:
157765
MDL number:
Assay:
~98%
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
1 M NaOH: 50 mg/mL, clear to slightly hazy
Storage temp.:
room temp
biological source
synthetic (organic)
Quality Level
grade
Hybri-Max™
sterility
γ-irradiated
product line
BioXtra
assay
~98%
form
lyophilized powder
concentration
50 ×
technique(s)
cell culture | hybridoma: suitable
impurities
endotoxin, tested
mp
≥300 °C (lit.)
solubility
1 M NaOH: 50 mg/mL, clear to slightly hazy
storage temp.
room temp
SMILES string
NC1=Nc2nc[nH]c2C(=S)N1
InChI
1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChI key
WYWHKKSPHMUBEB-UHFFFAOYSA-N
Gene Information
human ... IMPDH1(3614), IMPDH2(3615)
Application
在杂交瘤形成应用中作为选择剂。
Biochem/physiol Actions
核糖基化并通过与天然嘌呤碱相同的途径磷酸化；作为核苷酸，抑制参与核酸合成的多种细胞过程。作为白血病的有效治疗方法已有悠久的历史。
Preparation Note
10mL 无菌细胞培养基可复原一小瓶本品。储存液足以制备 500mL 培养基。最终工作浓度：30μM 2-氨基-6-巯基嘌呤。
Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine.
Nanne K H de Boer et al.
European journal of gastroenterology & hepatology, 17(4), 457-461 (2005-03-10)
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, approximately
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Reto Brem et al.
Cancer research, 72(18), 4787-4795 (2012-07-24)
The thiopurines azathioprine and 6-mercaptopurine have been extensively prescribed as immunosuppressant and anticancer agents for several decades. A third member of the thiopurine family, 6-thioguanine (6-TG), has been used less widely. Although known to be partly dependent on DNA mismatch
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A4660-2.5MG | 04061833374818 |