A4669
阿昔洛韦
≥99% (HPLC), DNA polymerase inhibitor, powder
别名:
9-[(2-羟基乙氧基)甲基]鸟嘌呤, 阿苷洛韦
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关于此项目
经验公式（希尔记法）:
C8H11N5O3
化学文摘社编号:
分子量:
225.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
261-685-1
MDL number:
产品名称
阿昔洛韦, ≥99% (HPLC), powder
Quality Level
assay
≥99% (HPLC)
form
powder
color
white
solubility
H2O: 0.7 mg/mL, 1 M HCl: 50 mg/mL, DMSO: 7 mg/mL
ε (extinction coefficient)
11.8 at 256 nm at 1 mM
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
originator
GlaxoSmithKline
SMILES string
NC1=Nc2c(ncn2COCCO)C(=O)N1
InChI
1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChI key
MKUXAQIIEYXACX-UHFFFAOYSA-N
Gene Information
human ... HV1S(3365), NP(4860)
General description
无环鸟苷或阿昔洛韦是一种鸟苷类似物。
Application
阿昔洛韦作为I型单纯疱疹病毒抑制剂的应用实例：
- 作为阳性对照，通过Vero细胞毒性检测法比较蘑菇提取物的抗病毒活性
- 在感染研究中，检测其对人背根神经节来源神经元(HD10.6)细胞的电压门控钠离子通道(VGSC)的影响
- 检测其对人包皮成纤维细胞的干扰素刺激基因(ISG)表达诱导（Mx1和ISG15）的影响
Biochem/physiol Actions
阿昔洛韦是一种抗病毒药，在单纯疱疹病毒胸苷激酶(HSV-TK)的作用下变成三磷酸阿昔洛韦。它竞争性地抑制病毒DNA聚合酶。它对巨细胞病毒和EB(Epstein-Barr)病毒的疗效相对较弱。阿昔洛韦已被用来研究单纯疱疹病毒的潜伏机制。它也具有抗人免疫缺陷型病毒1(HIV-1)活性。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A4669-100MG | 04061833374856 |
| A4669-500MG | 04061833374863 |
| A4669-50MG | 04061833374870 |