A5282
DL-2-氨基-5-膦酰戊酸
≥98% (TLC), solid, NMDA receptor antagonist
别名:
5-膦酰基-DL-正缬氨酸, DL-2-氨基-5-膦酰基缬草酸, AP-5, APV
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关于此项目
经验公式（希尔记法）:
C5H12NO5P
化学文摘社编号:
分子量:
197.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
2446389
Form:
solid
Quality level:
产品名称
DL-2-氨基-5-膦酰戊酸, solid
form
solid
Quality Level
color
white
solubility
0.1 M NaOH: 4 mg/mL, H2O: 5.6 mg/mL, organic solvents: insoluble
SMILES string
NC(CCCP(O)(O)=O)C(O)=O
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
InChI key
VOROEQBFPPIACJ-UHFFFAOYSA-N
Gene Information
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)
Application
DL-2-氨基-5-膦酰戊酸已用于：
- N-甲基-D-天冬氨酸(NMDA)介导突触灭活
- 用于生长培养基用于抑制神经元网络的电活性
- 用于分离N-甲基-D-天冬氨酸受体(NMDAR)或α-氨基-3-羟基-5-甲基-4-异噁唑丙酸受体(AMPAR)介导电流
- 溶于双蒸水中，与朊蛋白(PrPC)比较其NMDA拮抗作用
Biochem/physiol Actions
镇痉；有效的选择性NMDA受体拮抗剂。
Other Notes
Disclaimer
吸湿
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
Weitlauf C, et al.
The Journal of Neuroscience, 25(37), 8386-8390 (2005)
Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays
Shein M, et al.
Biomedical Microdevices, 11(2), 495-501 (2009)
Maria José Diógenes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11750-11762 (2012-08-24)
Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A5282-50MG | 04061833375693 |
| A5282-100MG | 04061833375662 |
| A5282-10MG | 04061833375679 |
| A5282-25MG | 04061833375686 |