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A5835

γ-氨基丁酸

Name: &#947;-氨基丁酸
Brand: SIGMA

≥99%, suitable for ligand binding assays, BioXtra

别名:

3-羧丙胺, 4-氨基丁酸, GABA, 哌啶酸, 氨酪酸

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关于此项目

线性分子式:

NH₂(CH₂)₃COOH

化学文摘社编号:

56-12-2

分子量:

103.12

NACRES:

NA.26

PubChem Substance ID:

24891025

UNSPSC Code:

12352106

EC Number:

200-258-6

MDL number:

MFCD00008226

Beilstein/REAXYS Number:

906818

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属性

产品名称

γ-氨基丁酸, BioXtra, ≥99%

product line

BioXtra

Quality Level

200

assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

impurities

<0.0005% Phosphorus (P), <0.1% Insoluble matter

ign. residue

<0.1%

color

white

mp

195 °C (dec.) (lit.)

solubility

H₂O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): <0.04%, sulfate (SO₄^2-): <0.05%

cation traces

Al: <5 mg/kg, Ca: <20 mg/kg, Cu: <5 mg/kg, Fe: <5 mg/kg, K: <50 mg/kg, Mg: <50 mg/kg, NH₄⁺: <500 mg/kg, Na: <70 mg/kg, Pb: <10 mg/kg, Zn: <5 mg/kg

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Gene Information

human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

说明

General description

γγ-氨基丁酸(GABA)是一种与大脑有关的非蛋白质氨基酸。在神经系统中合成，贮存于突触囊泡中。天然存在于绿茶、大豆、发芽稻米和一些发酵食品中。

Application

γγ-氨基丁酸(GABA)已用于处理背根神经节神经元进行电生理记录研究，以研究其对大鼠神经病理性疼痛的影响。它还用于检测其在小体积移植(SFSG)损伤模型的离体机械灌注系统中的保护作用。

Biochem/physiol Actions

γγ-氨基丁酸（GABA）是一种哺乳动物抑制性神经递质，具有多种功能。它对于中枢神经系统(CNS)的正常功能发挥至关重要。文献记录的GABA功能包括它在毒素诱导损伤中的保护作用。它还具有抗高血压、抗糖尿、抗微生物、抗氧化、抗过敏、抗炎和抗癌作用。GABA可能有益于人的压力和睡眠改善。γγ-氨基丁酸(GABA)可用于研究由GABA受体——GABAA和GABAB——介导的生物和生化过程。

大脑中的主要抑制性神经递质；GABA_A 和 GABA_B受体激动剂；增加 Cl⁻ 的传导性。

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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.

Piril Hepsomali et al.

Frontiers in neuroscience, 14, 923-923 (2020-10-13)

Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role

Effects of niflumic acid on γ-aminobutyric acid-induced currents in isolated dorsal root ganglion neurons of neuropathic pain rats.

Li-Jie Wang et al.

Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)

Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess

A disinhibitory mechanism biases Drosophila innate light preference.

Weiqiao Zhao et al.

Nature communications, 10(1), 124-124 (2019-01-12)

Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is

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全球贸易项目编号

货号	GTIN
A5835-100G	04061833376515
A5835-10G	04061833376522
A5835-10MG	04061833617021
A5835-25G	04061833376539