A5845
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin
≥95% (HPLC), powder
别名:
Ac-LEHD-AFC
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关于此项目
经验公式（希尔记法）:
C33H38O11N7F3
分子量:
765.69
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white
solubility
DMSO/DMF: 20 mM
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2
InChI
1S/C33H38F3N7O11/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48)/t21-,22-,23-,24-/m0/s1
InChI key
HULKIXRFKRCRHD-ZJZGAYNASA-N
Gene Information
human ... CARD9(64170), CASP9(842)
mouse ... CARD9(332579), CASP9(12371)
rat ... CARD9(64171), CASP9(58918)
General description
Amino acid derivatives of 7-amido-4-trifluoromethylcoumarin (AFC) are blue in fluorescence microscopy.
Application
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin has been used to assay caspase 9 activity using a substrate-based fluorimetric detection assay
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Faezeh Attaran-Bandarabadi et al.
International journal of biological macromolecules, 101, 283-289 (2017-03-23)
Contribution of individual BIR domains to Smac antagonism is investigated. Ammonium citrate was used to activate caspase-9 and pro-caspase-9 (D315, D330/A). However, the presence of citrate resulted in autoproteolysis of pro-caspase-9 and its inhibition by XIAP BIR3, which was not
Jianguo Li et al.
Molecular medicine reports, 10(3), 1433-1437 (2014-06-19)
There is increasing evidence that neuronal cell death occurs via extrinsic (death receptors) and intrinsic (mitochondria) pathways. Radiation induces caspase activation fundamentally via the mitochondrial pathway. Caspases are the key regulators of apoptosis. Healthy male Sprague‑Dawley rats were used in
Ke Wang et al.
Scientific reports, 6, 37927-37927 (2016-12-08)
Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo is unknown. We aim to observe
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A5845-5MG | 04061833267455 |