A6706
O-乙酰基-L-肉碱盐酸盐 盐酸盐
≥99% (titration)
别名:
乙酰 L-肉碱盐酸盐, (R)-3-乙酰氧基-4-（三甲基铵）丁酸酯 盐酸盐, ALC, ALCAR, R-(-)-2-乙酰氧基-3-羧基- N,N,N -三甲基-1-丙胺氯化物
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关于此项目
经验公式（希尔记法）:
C9H17NO4 · HCl
化学文摘社编号:
分子量:
239.70
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Beilstein/REAXYS Number:
4340103
产品名称
O-乙酰基-L-肉碱盐酸盐 盐酸盐, ≥99% (titration), powder
biological source
synthetic
Quality Level
assay
≥99% (titration)
form
powder
optical activity
[α]25/D −28°, c = 2 in H2O(lit.)
color
white to off-white
mp
194 °C
solubility
H2O: 100 mg/mL
application(s)
cell analysis
storage temp.
2-8°C
SMILES string
C[N+](C)(C)C[C@H](OC(C)=O)CC(O)=O.[Cl-]
InChI
1S/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/m1./s1
InChI key
JATPLOXBFFRHDN-DDWIOCJRSA-N
General description
乙酰-L-肉碱(ALC/ALCAR)是一种类维生素，作为肉碱代谢物存在于哺乳动物血浆和组织中。它是L-肉碱(LC)的乙酰形式。ALCAR可用作膳食补充剂。它以高浓度存在于下丘脑中。
Application
O-乙酰-L-肉碱盐酸盐已用于：
- 作为生物活性分子体外研究其对B淋巴母细胞样细胞系(BLCL)增殖的影响以及对流感病毒特异性人B和T细胞免疫应答的调节作用
- 作为体外成熟(IVM)培养基组分，研究其对羔羊卵母细胞囊胚率、超微结构和线粒体DNA拷贝数的影响
- 作为代谢物/化学标准品对鼠肿瘤组织间液中的代谢物水平进行定量分析
Biochem/physiol Actions
乙酰左旋肉碱(ALC)在中间代谢和提高女性生育力中起重要作用。女性生殖系统的氧化和代谢状态受到ALC调控。ALC具有拟胆碱和抗炎功效。它可调控γ-氨基丁酸(GABA)系统。ALC能调节大脑的葡萄糖利用率。ALC对发育大脑具有神经保护作用。
通过线粒体膜转运乙酰基的内源性线粒体代谢物。
通过线粒体膜转运乙酰基的内源性线粒体代谢物。外源性乙酰肉碱增强老年大鼠线粒体功能。作为辅酶 A 的醋酸盐供体，增加中枢和外周乙酰胆碱合成和功能。乙酰肉碱具有抗伤害感受性活性，可能通过增强毒蕈碱胆碱能受体或 mGlu2 谷氨酸受体的活性介导。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Role of L-carnitine in female infertility
Agarwal A, et al.
Reproductive Biology and Endocrinology, 16 (2018)
Lais Pancotto et al.
PeerJ, 6, e5309-e5309 (2018-08-08)
Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Acetyl-L-carnitine (ALC) is a multi-target molecule that modulates
Nobuaki Miyaji et al.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 27(11), 3426-3431 (2019-02-06)
The purpose of this study was to quantitatively compare the results of pivot-shift test between knees with anterior cruciate ligament (ACL) injury with and without anterolateral capsule (ALC) injury detected on MRI. ALC injury was hypothesized to worsen rotatory knee
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A6706-1G | 04061833382745 |
| A6706-5G | 04061832421186 |