biological source
rabbit
Quality Level
conjugate
agarose conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
analyte chemical class(es)
proteins (c-Myc)
technique(s)
affinity chromatography: suitable, immunoprecipitation (IP): suitable
capacity
≥10 nmol/mL binding capacity (c-Myc tagged fusion protein), ≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... MYC(4609)
General description
人c-Myc原癌基因属于MYC癌基因家族，是在几种致白血病逆转录病毒中发现的禽v-Myc基因的人细胞同源物。c-Myc基因位于人类染色体8q24.21。其两个主结构域包括具有螺旋-环-螺旋/亮氨酸-拉链基序的N末端盒区域和C末端基本区域
Immunogen
人p62c-Myc蛋白的合成肽。
Application
兔源抗c-Myc琼脂糖亲和凝胶抗体已用于：
- 染色质免疫沉淀 (ChIP)
- 免疫共沉淀
- 蛋白质印迹
- 免疫荧光
- 免疫沉淀
Biochem/physiol Actions
抗c-Myc可识别位于c-Myc标记融合蛋白上的表位。
许多人类肿瘤中观察到c-Myc原癌基因表达增加。在血管肉瘤中观察到Myc基因位点扩增，在伯基特氏淋巴瘤中Myc基因位点出现易位。c-Myc是主要的调控基因，可靶向多种代谢事件。位于人c-Myc氨基酸残基410-419（EQKLISEEDL）内的表位已在许多表达载体中广泛用作标签，使蛋白质能够作为c-Myc标记融合蛋白进行表达。抗c-Myc琼脂糖可用于纯化细菌裂解液或转染细胞中表达的c-Myc标记融合蛋白。
Physical form
悬浮的琼脂糖颗粒(1：1，v/v)溶于0.01 M磷酸盐缓冲液中，含有15mM叠氮化钠。
Preparation Note
为持续使用并延长存储时间，请2°C至8°C存储。请勿冷冻。
Other Notes
Disclaimer
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A7470-1ML | 04061833384640 |