A8523
阿莫西林
95.0-102.0% anhydrous basis
别名:
Amoxicillin anhydrous, D-(-)-α-Amino-p-hydroxybenzyl penicillin
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关于此项目
经验公式（希尔记法）:
C16H19N3O5S
化学文摘社编号:
分子量:
365.40
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
248-003-8
Beilstein/REAXYS Number:
7507120
MDL number:
Quality Level
assay
95.0-102.0% anhydrous basis
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O
InChI
1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1
InChI key
LSQZJLSUYDQPKJ-NJBDSQKTSA-N
General description
Chemical structure: β-lactam
Application
Amoxicillin is used to study the oxygen dependent antimicrobial systems of polymorphonuclear leukocytes (PMNLs), the risk of resistance development in Helicobacter pylori, and various dosing strategies against Streptococcus pneumoniae and Pneumococcal pneumonia . It is also used to study the synthesis of bacterial cell walls at the level of peptidoglycan polymer chain cross-linking involving bacterial transpeptidase.
Biochem/physiol Actions
Amoxicillin is a broad-spectrum, β-lactam antibiotic. It is a 4-hydroxy analog of ampicillin with similar ranges of actions and utility to ampicillin. Amoxicillin inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Heather K Sun et al.
The Journal of antimicrobial chemotherapy, 56(3), 559-565 (2005-07-19)
Amoxicillin and clarithromycin have been proven to be effective in the treatment of community-acquired pneumonia. This study investigated the in vivo bactericidal efficacy of a novel, pulsatile dosing strategy for amoxicillin and clarithromycin, when used as monotherapy and combination therapy.
Jose-Manuel Rodriguez-Martinez et al.
Antimicrobial agents and chemotherapy, 54(1), 471-476 (2009-11-18)
Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1
Thierry Naas et al.
Antimicrobial agents and chemotherapy, 52(4), 1257-1263 (2008-01-30)
Genetic structures surrounding the carbapenem-hydrolyzing Ambler class A bla KPC gene were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas aeruginosa strains isolated from the United States, Colombia, and Greece. The bla KPC genes were associated in all cases with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A8523-25G | 04061833392041 |
| A8523-5G | 04061833392089 |
| A8523-10G | 04061834427742 |
| A8523-1G | 04061833392034 |