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A8843

AM580

Name: AM580
Brand: SIGMA

≥98% (HPLC), RAR-α agonist, solid

别名:

4- [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）甲酰胺基] 苯甲酸

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₅NO₃

化学文摘社编号:

102121-60-8

分子量:

351.44

UNSPSC Code:

12352200

PubChem Substance ID:

24891374

NACRES:

NA.77

MDL number:

MFCD00673916

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

200

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属性

产品名称

AM580, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O

InChI

1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChI key

SZWKGOZKRMMLAJ-UHFFFAOYSA-N

Gene Information

human ... RARA(5914), RARB(5915)

说明

General description

AM580是视黄苯甲酸衍生物和RAR-α（视黄酸受体-α）激动剂。它刺激 NB4 早幼粒细胞白血病细胞系和 APL（急性早幼粒细胞白血病）原始细胞中粒细胞的成熟。AM580 抑制子宫内膜癌细胞增殖。

Application

类视黄醇衍生物用于白血病-视黄酸受体 (PHL-RAR) 细胞系分化的基因表达研究。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha.

Marie Virtanen et al.

Experimental dermatology, 19(7), 674-681 (2010-05-12)

Disorders of keratinization are often treated with vitamin A derivatives (retinoids) which affect keratinocyte differentiation, including keratin (KRT) gene expression. In vivo, suprabasal keratinocytes normally express only keratin (K) 1, K2 and K10, but after topical application of all-trans retinoic

Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8

Yasmeen G Ghnewa et al.

Clinical immunology (Orlando, Fla.), 183, 91-98 (2017-08-07)

Invariant natural killer T (iNKT) cells are cytotoxic T cells that respond to glycolipid antigens presented by CD1d. Therapeutic activation of iNKT cells with α-galactosylceramide (α-GalCer) can prevent and reverse tumor growth in mice and clinical trials involving α-GalCer-stimulated iNKT

Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.

Reinhold Tacke et al.

ChemMedChem, 4(11), 1797-1802 (2009-10-01)

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全球贸易项目编号

货号	GTIN
A8843-5MG	04061832952970