A8861
Aceclofenac
≥98% (HPLC), anti-inflammatory drug, powder
别名:
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C16H13Cl2NO4
化学文摘社编号:
分子量:
354.18
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Aceclofenac, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
InChI key
MNIPYSSQXLZQLJ-UHFFFAOYSA-N
Gene Information
human ... PTGS2(5743)
Application
Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.
Biochem/physiol Actions
Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
flash_point_c
Not applicable
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
K Karthikeyan et al.
AAPS PharmSciTech, 13(1), 143-149 (2011-12-15)
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability
Kyung Rok Chu et al.
Archives of pharmacal research, 35(7), 1187-1195 (2012-08-07)
This study examined the effects of the particle size of various poorly water-soluble drugs on their dissolution behavior through physicochemical and mathematical analysis. As model drugs, hydrochlorothiazide, aceclofenac, ibuprofen and a discovery candidate were selected. The materials were crystallized using
R N Brogden et al.
Drugs, 52(1), 113-124 (1996-07-01)
Aceclofenac is a phenylacetic acid derivative with anti-inflammatory and analgesic properties similar to those of diclofenac. However, preclinical studies suggest that the potential of aceclofenac to cause gastrointestinal damage is less than that of diclofenac. Double-blind comparative trials indicate that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A8861-10MG | 04061833400869 |
| A8861-50MG | 04061833400876 |