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Merck
CN

A9522

Anti-Antithrombin III antibody produced in rabbit

fractionated antiserum, lyophilized powder

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i)
Citations:
9
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

packaging

vial of 2 mL lyophilized antiserum

technique(s)

indirect ELISA: 1:25,000

UniProt accession no.

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... SERPINC1(462)

General description

Antithrombin III (ATIII) is a small glycoprotein produced by the liver that functions as a serine protease inhibitor to block coagulation.
Antithrombin III is a 58kDa glycoprotein synthesized in the liver. It has two domains, a heparin-binding domain and target protease binding domain.

Immunogen

human antithrombin III

Application

Anti-Antithrombin III antibody has been used in western blotting and antigenic assay.

Biochem/physiol Actions

Antithrombin III is a serine protease inhibitor which affects many intrinsic and extrinsic blood coagulation pathways. It inactivates the function of thrombin and factor X in blood. Severe sepsis is caused due to lack of antithrombin III.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Preparation Note

Reconstitute with 2 mL deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
低风险生物材料

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Defects of splicing in antithrombin deficiency
de la Morena-Barrio M E, et al.
Research and practice in thrombosis and haemostasis, 1(2), 216-222 (2017)
Mara Toderici et al.
PloS one, 11(3), e0152159-e0152159 (2016-03-24)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the
Antithrombin III in patients with severe sepsis
Eisele B, et al.
Intensive Care Medicine, 24(7), 663-672 (1998)



全球贸易项目编号

货号GTIN
A9522-1VL04061838160973