A9770
乙醛脱氢酶，钾-激活 来源于酵母
lyophilized powder, ≥10 units/mg protein
别名:
ALDH, 不依赖CoA的醛脱氢酶, 间甲基苯甲醛脱氢酶, 乙醛：NAD[P]+氧化还原酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-846-3
MDL number:
Specific activity:
≥10 units/mg protein
Biological source:
yeast
biological source
yeast
Quality Level
form
lyophilized powder
specific activity
≥10 units/mg protein
storage condition
(Tightly closed. Dry)
color
white
UniProt accession no.
foreign activity
NADH oxidase ≤0.01%, NADPH oxidase ≤0.01%, alcohol dehydrogenase ≤0.01%, lactic dehydrogenase ≤0.01%
storage temp.
2-8°C
General description
乙醛脱氢酶(ALDH)家族包含人类19个基因。它位于细胞的细胞核、细胞质、线粒体和内质网中。
研究领域：细胞信号传导
研究领域：细胞信号传导
酵母来源乙醛脱氢酶用于催化许多种底物氧化，比如乙醛、甲醛、丙醛、正丁醛、异丁醛、N-戊醛、己醛、苯甲醛、糖醛、D-甘油醛、丙二酸半醛和丁二酸醛。酵母来源乙醛脱氢酶用于研究乙醇和异丁醇生产。Sigma的乙醛脱氢酶可结合乙醇脱氢酶测定白色念珠菌(Candida albicans)糖酵解代谢和离子转运过程中的乙醇生产。
Application
酵母来源钾活化乙醛脱氢酶已用于：
- 固定酶和氧化甲醛以形成甲酸酯
- 研究与腙之间的作用关系
- 测定乙醇生成。
Biochem/physiol Actions
乙醛脱氢酶(ALDH)调节非P450醛还原酶系统。它可保护细胞免受有毒乙醛的影响。该基因的突变会导致Sjogren‐Larsson综合征、Larsson综合征、II型高脯胺酸血症和癌症。乙醛脱氢酶2可减轻心肌梗死或心脏手术后的心肌缺血性损伤。乙醛脱氢酶(ALDH)在免疫系统中参与调节性T细胞功能。还参与细胞解毒、氨基酸代谢，并保护细胞免遭紫外线(UV)诱导损伤。ALDH与视黄酸生物合成和信号传导有关。
乙醛脱氢酶是一种四聚体，有几种不同的亚型。乙醛脱氢酶被丙脲，巴豆醛，异氰酸正丙酯，异氰酸环己酯，1-n-丙基-1-[（4-氯苯基）磺酰]-3-n-丙基脲和1-甲基-1-[（4-氯苯基）磺酰]-3-n-丙基脲抑制。该酶在0.01M焦磷酸盐缓冲液中检测，表现为在pH9.3有最大峰值，乙醛为底物。
Physical form
含有磷酸钾盐
Other Notes
在pH 8.0、25摄氏度条件下，一单位每分钟可1微摩尔乙醛氧化为乙酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9770-100UN | 04061833412343 |
| A9770-250UN | 04061833412350 |
| A9770-25UN | 04061833412367 |