biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
solubility
water: 25 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
Cl[H].CC1CCN=C(N)S1
InChI
1S/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H
InChI key
HVJCRMIQAMEJNM-UHFFFAOYSA-N
Gene Information
human ... FPGS(2356)
Biochem/physiol Actions
As a selective type II (inducible) nitric oxide synthase (NOS) inhibitor, AMT was tested against LPS-induced inflammation in rats.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
W R Tracey et al.
Canadian journal of physiology and pharmacology, 73(5), 665-669 (1995-05-01)
Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit
M Nakane et al.
Molecular pharmacology, 47(4), 831-834 (1995-04-01)
We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were obtained with partially purified preparations of inducible nitric oxide synthase.
Ju Hee Lee et al.
Archives of pharmacal research, 38(7), 1304-1311 (2015-03-07)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9834-10MG | 04061833267660 |