biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
82 kDa
species reactivity
rabbit, horse, guinea pig, rat, human, bovine, dog, mouse
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SIRT1(23411)
General description
Sirtuin（沉默交配型信息调节2同源物）1（ 酿酒酵母）（SIRT1）是NAD（+）依赖性蛋白脱乙酰酶SIRT家族的成员，参与调节涉及能量代谢的基因的核转录。 SIRT1提供了细胞能量状态感知（NAD（+）状态）与能量稳态调节之间的联系。SIRT1参与代谢、细胞分化和衰老、应激反应和癌症的调节。
兔多克隆抗SIRT1抗体可与鸡，人，小鼠，大鼠，犬和猪的sirtuin-1酶反应。
Immunogen
靶向人SIRT1 N末端区域的合成肽
Application
兔多克隆抗SIRT1抗体用于标记sirtuin-1，以通过免疫细胞化学和免疫组化（IHC）技术进行检测和定量。它被用作探针来确定sirtuin-1在核转录控制和蛋白脱乙酰化水平上NAD（+）状态依赖性能量稳态中的存在和作用。
兔抗SIRT1抗体可在0.5 μg/ml浓度下用于蛋白质印迹应用。
Biochem/physiol Actions
SIRT1是sirtuin蛋白家族的成员，与酵母Sir2蛋白同源。sirtuin家族的成员以sirtuin核心域为特征，分为四类。人类sirtuins的功能尚未确定。
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
Other Notes
合成肽位于以下区域内： PETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKI
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Still not finding the right product?
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
常规特殊物品
此项目有
Éverton Lopes Vogt et al.
International journal of environmental research and public health, 18(14) (2021-07-25)
Introduction and objectives: Obesity represents a major global public health problem. Its etiology is multifactorial and includes poor dietary habits, such as hypercaloric and hyperlipidic diets (HFDs), physical inactivity, and genetic factors. Regular exercise is, per se, a tool for
Knut H Lauritzen et al.
Neurobiology of aging, 48, 34-47 (2016-09-18)
Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we
Hongyi Zhang et al.
International journal of oncology, 45(5), 2143-2152 (2014-08-15)
MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AV32386-100UL | 04061836179564 |