AV50523
Anti-SPRY2 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-MGC23039, Anti-Sprouty homolog 2 (Drosophila), Anti-hSPRY2
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
35 kDa
species reactivity
rat, dog, pig, mouse, human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SPRY2(10253)
General description
The gene SPRY2 (Sprouty homolog 2) is mapped to human chromosome 13q31.1. SPRY2 localizes in the cytoplasm and co-localizes with microtubules.
Immunogen
Synthetic peptide directed towards the N terminal region of human SPRY2
Application
Anti-SPRY2 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.
Biochem/physiol Actions
Sprouty proteins are inhibitors of receptor tyrosine kinase signaling proteins and mediators of organogenesis, branching of lung alveoli and endothelial tubes. They inhibit the activity of Ras/Erk pathway. SPRY2 (Sprouty homolog 2) is bimodal regulator of epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase signaling. SPRY2 is down-regulated in epithelial ovarian cancer. Down-regulation of SPRY2 in high-grade serous ovarian carcinoma promotes EGF-induced E-cadherin levels, thereby resulting in cell invasion.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIR
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Samar Masoumi-Moghaddam et al.
International journal of cancer, 137(3), 560-570 (2015-01-30)
Sprouty proteins are evolutionary-conserved modulators of receptor tyrosine kinase signaling, deregulation of which has been implicated in the pathophysiology of cancer. In the present study, the expression status of Spry2 and Spry4 proteins and its clinical relevance in human epithelial
Wai-Kin So et al.
FEBS letters, 589(3), 302-309 (2014-12-24)
Sprouty (SPRY) proteins are well-characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence-Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down-regulated in high-grade serous ovarian carcinoma
J Lim et al.
The Journal of biological chemistry, 275(42), 32837-32845 (2000-07-11)
Sprouty (Spry) was first identified in a genetic screen in Drosophila to be an antagonist of fibroblast growth factor and epidermal growth factor (EGF) signaling, seemingly by inhibiting the Ras/MAP kinase pathway. Data base searches lead to the identification and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AV50523-100UL | 04061836203801 |