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B133

（S）-（−）-Bay K8644

≥98% (HPLC), Ca2+ channel activator, solid

别名:

S-（−）-1，4-二氢-2，6-二甲基-5-硝基-4-[2-（三氟甲基）苯基]-3-吡啶甲酸甲酯

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关于此项目

经验公式（希尔记法）:
C16H15F3N2O4
化学文摘社编号:
98625-26-4
分子量:
356.30
UNSPSC Code:
12352200
PubChem Substance ID:
24891582
NACRES:
NA.77
MDL number:
MFCD00153769
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
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产品名称

（S）-（−）-Bay K8644, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

H2O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)

storage temp.

2-8°C

SMILES string

COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O

InChI

1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1

InChI key

ZFLWDHHVRRZMEI-ZDUSSCGKSA-N

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)

General description

（S）-（-）-Bay K8644，一种二氢吡啶化合物，是一种Ca2+ 通道激活剂。它是Bay K 8644的对映异构体。

Application

（S）-（-）-Bay K8644已被用作视交叉上核（SCN）切片中的L型钙通道（LTCC）激动剂。它也被用作LTCC激动剂以诱导大鼠心律失常。

Biochem/physiol Actions

（S）-（-）-Bay K8644增强Ca2+电流，而（+）-Bay K 8644是弱Ca2+通道拮抗剂。Bay K 8644具有亲脂性，可有效清除超氧阴离子。

Features and Benefits

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面，请点击此处。

Legal Information

经Bayer AG许可生产和销售。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
112M4720V
030M46261
030M4626
107K46213
107K46212

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Joshua P Whitt et al.
The Journal of general physiology, 150(2), 259-275 (2017-12-15)
Large conductance K+ (BK) channels are expressed widely in neurons, where their activation is regulated by membrane depolarization and intracellular Ca2+ (Ca2+i). To enable this regulation, BK channels functionally couple to both voltage-gated Ca2+ channels (VGCCs) and channels mediating Ca2+
J Ferrante et al.
Biochemical and biophysical research communications, 158(1), 149-154 (1989-01-16)
The 1,4-dihydropyridine Ca2+ channel activator, (-) [3H]Bay K 8644, binds to cardiac membranes and polarized [5 mM K+] and depolarized [50 mM K+] cardiac cells. Binding to microsomal membranes at 25 degrees C indicates a single set of binding sites
Meng Xu et al.
Chinese medical journal, 124(21), 3455-3459 (2012-02-22)
It has been reported that endogenous or exogenous hydrogen sulfide (H(2)S) exerts physiological effects in the vertebrate cardiovascular system. We have also demonstrated that H(2)S acts as an important regulator of electrophysiological properties in guinea pig papillary muscles and on
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全球贸易项目编号

货号GTIN
B133-1MG04061826671177
B133-5MG04061832960210