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B134

BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

别名:

8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₂H₃₁N₃O₃ · 2HCl

化学文摘社编号:

21102-95-4

分子量:

458.42

NACRES:

NA.77

PubChem Substance ID:

24278080

UNSPSC Code:

12352200

MDL number:

MFCD00153771

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: >5 mg/mL

SMILES string

Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O

InChI

1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H

InChI key

NIBOMXUDFLRHRV-UHFFFAOYSA-N

Gene Information

human ... ADRA1D(146), HTR1A(3350)

说明

Biochem/physiol Actions

BMY 7378 dihydrochloride is a partial 5-HT_1A serotonin receptor agonist and selective α_1D-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bristol Myers Squibb Corporation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.

M J Millan et al.

The Journal of pharmacology and experimental therapeutics, 268(1), 337-352 (1994-01-01)

The novel benzodioxopiperazines [4-(benzodioxan-5-yl)1-[2- (benzocyclobutane-1-yl)ethyl]piperazine] (S 14489), [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine)] (S 15535) and [4-(benzodioxan-5-yl)1-[2(indan-1-yl)ethyl]piperazine (S15931) competitively displaced the binding of [3H]-8-OH-DPAT at serotonin (5-HT)1A receptors with affinities (pKis) of 9.2, 8.8 and 8.9, respectively. These values compared favorably with those of the

BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes.

F D Yocca et al.

European journal of pharmacology, 137(2-3), 293-294 (1987-06-04)

Buspirone functionally discriminates tissues endowed with alpha1-adrenoceptor subtypes A, B, D and L.

M Eltze et al.

European journal of pharmacology, 378(1), 69-83 (1999-09-09)

The affinity for functional alpha1-adrenoceptor subtypes of buspirone in comparison with its close structural analogs and selective alpha1D-adrenoceptor antagonists, BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]dec ane-7,9-dione) and MDL 73005EF (8-[2-(1,4-benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro+ ++[4.5]decane-7,9-dione), was determined, namely at subtype A in rat vas deferens and perfused

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全球贸易项目编号

货号	GTIN
B134-100MG	04061833422168
B134-25MG	04061833422175