B150
BQ-123
≥99%, sodium salt, lyophilized powder
别名:
BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)
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关于此项目
经验公式（希尔记法）:
C31H41N6O7 Na
化学文摘社编号:
分子量:
632.68
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Quality Level
assay
≥99%
form
lyophilized powder
storage temp.
−20°C
SMILES string
[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
InChI
1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
InChI key
VYCMAAOURFJIHD-PJNXIOHISA-N
Gene Information
human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)
Application
BQ-123已用作选择性内皮素-A受体拮抗剂，研究其对肿瘤坏死因子α(TNFα)诱导的人气道平滑肌细胞(HASMC)增殖的影响。作为内皮素-A受体拮抗剂，它还用于研究其对TNFα诱导的粒细胞-巨噬细胞集落刺激因子(GM-CSF) 表达的影响。
Biochem/physiol Actions
BQ-123是一种内皮素(Et)受体拮抗剂，对内皮素A(ETA)受体敏感。它是一种环五肽。
选择性ETA内皮素受体拮抗剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B150-1MG | 04061835435746 |
| B150-200UG | 04061833426128 |