B1686
BIO
≥98% (HPLC), powder, GSK-3α/β inhibitor
别名:
(2’Z,3’E)-6-溴靛玉红-3′-肟, 6-BIO, 6BIO
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关于此项目
经验公式（希尔记法）:
C16H10BrN3O2
化学文摘社编号:
分子量:
356.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
BIO, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
dark red
solubility
DMSO: >5 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34
InChI
1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
InChI key
DDLZLOKCJHBUHD-WAVHTBQISA-N
Application
6-溴靛玉红-3′-肟(BIO)已用于以下情形：
- MTT 3-(4,5-二甲基噻唑-2- 基)-2,5-联苯四唑溴化物)细胞增殖实验
- 胚胎干细胞(ESC)的培养基补充剂
- 抑制人真皮乳头细胞(hDPC)中的糖原合成酶激酶3 β (GSK-3β)
Biochem/physiol Actions
6-溴靛玉红-3′-肟（BIO）是一种有效的、可逆的、ATP竞争性GSK-3α/β抑制剂，并且是第一种能够维持人和小鼠胚胎干细胞自我更新的药物。通过在无饲养层条件下用GSK-3抑制剂BIO处理，能够将人胚胎干细胞（hESC）维持在未分化状态。
BIO是一种有效的、选择性的、可逆的、ATP竞争性GSK-3α/β抑制剂。
Features and Benefits
该化合物是激酶磷酸酶生物学研究推荐产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
Packaging
空气敏感
Legal Information
本品适用于 体外 研究和实验室用途，不得用于人类的任何 体内 或治疗用途、兽医应用或制造化学衍生物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B1686-25MG | 04061832444529 |
| B1686-5MG | 04061833426319 |