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B1758

Biocytin hydrochloride

Name: Biocytin hydrochloride
Brand: SIGMA

≥98% (TLC), suitable for drug transporter assays

别名:

N_ε-Biotinyl-L-lysine

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₈N₄O₄S · xHCl

化学文摘社编号:

98930-70-2

分子量:

372.48 (free base basis)

UNSPSC Code:

12352209

PubChem Substance ID:

24891609

NACRES:

NA.26

MDL number:

MFCD00136057

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属性

产品名称

Biocytin hydrochloride, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

technique(s)

drug transporter assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O

InChI

1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H

InChI key

FMGQMNFQNPUYBS-UHFFFAOYSA-N

说明

Application

Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).

Biochem/physiol Actions

Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Shaping of discrete auditory inputs to extramodular zones of the lateral cortex of the inferior colliculus.

Isabel D Lamb-Echegaray et al.

Brain structure & function, 224(9), 3353-3371 (2019-11-16)

The multimodal lateral cortex of the inferior colliculus (LCIC) exhibits a modular-extramodular micro-organization that is evident early in development. In addition to a set of neurochemical markers that reliably highlight its modular-extramodular organization (e.g. modules: GAD67-positive, extramodular zones: calretinin-positive, CR)

Biocytin and biotin uptake into NB2a neuroblastoma and C6 astrocytoma cells.

Barbara Baur et al.

Brain research, 925(2), 111-121 (2002-01-17)

Uptake of biocytin and biotin was investigated in cultured transformed variants of neuronal (NB2a neuroblastoma) and glial (C6 astrocytoma) CNS cells. NB2a cells took up both compounds but biocytin was transported more efficiently than biotin in the nanomolar concentration range.

Serum biotinidase activity in children with chronic liver disease and its clinical significance.

Aysun Pabuçcuoğlu et al.

Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)

Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased

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全球贸易项目编号

货号	GTIN
B1758-100MG	04061833426340
B1758-25MG	04061832415161
B1758-250MG	04061833426357
B1758-50MG	04061832415178