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B1760

苯并[a]芘

Name: 苯并[<I>a</I>]芘
Brand: SIGMA

≥96% (HPLC)

别名:

3,4-苯并芘, 苯并[det]屈, 苯并芘

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₂

化学文摘社编号:

50-32-8

分子量:

252.31

UNSPSC Code:

12352005

NACRES:

NA.25

PubChem Substance ID:

24891610

EC Number:

200-028-5

Beilstein/REAXYS Number:

1911333

MDL number:

MFCD00003602

Assay:

≥96% (HPLC)

Form:

solid

Quality level:

200

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属性

Quality Level

200

assay

≥96% (HPLC)

form

solid

bp

495 °C (lit.)

mp

177-180 °C (lit.)

SMILES string

c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45

InChI

1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H

InChI key

FMMWHPNWAFZXNH-UHFFFAOYSA-N

说明

Application

苯并(a)芘（PAH），是一种聚环芳烃污染物，在癌症实验模型中作为化学致癌剂。致癌作用取决于它的氧化反应，CYP1A1转化成苯并(a)芘二醇环氧化物，和DNA形成去嘌呤加成，解离形成坏疽性病变。苯并(a)芘是多环芳香烃受体（AhR）配体，它的一些生物效应，包括诱发CYP1A1，通过AHR活化调节。

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pictograms

GHS08,GHS07,GHS09

signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

hcodes

H317,H340,H350,H360FD,H410,EUH441

pcodes

P201 - P202 - P273 - P280 - P308 + P313 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - PBT - Repr. 1B - Skin Sens. 1 - vPvB

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels.

Audrey Barranger et al.

Nanomaterials (Basel, Switzerland), 9(7) (2019-07-11)

This study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into tissues was confirmed by Gas

Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.

Ariel Revel et al.

Journal of applied toxicology : JAT, 23(4), 255-261 (2003-07-29)

Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Because BaP metabolization requires cytochrome

beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity.

Yuji Fujita et al.

Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12)

The physiological role of aryl hydrocarbon receptor (AhR) is not yet fully understood, and investigation is hampered by the limited solubility of reported AhR ligands in aqueous media. To achieve improved solubility, we focused on our previous finding that planarity-disruption

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全球贸易项目编号

货号	GTIN
B1760-100MG	04061833426364
B1760-250MG	04061833426371
B1760-1G	04061835542826
B1760-500MG	04061833426388
B1760-5G	04061835512171

主要文件

苯并[a]芘

≥96% (HPLC)

选择尺寸

关于此项目

Quality Level

assay

form

bp

mp

SMILES string

InChI

InChI key

Application

Still not finding the right product?

安全信息

pictograms

signalword

存储类别

flash_point_f

flash_point_c

hcodes

pcodes

Hazard Classifications

文件

分析证书(COA)

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