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B2292

O6-苄基鸟嘌呤

≥98% (TLC), solid, O⁶-alkylguanine DNA alkyltransferase inhiitor

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关于此项目

经验公式（希尔记法）:
C12H11N5O
化学文摘社编号:
19916-73-5
分子量:
241.25
UNSPSC Code:
12352200
PubChem Substance ID:
24278259
NACRES:
NA.77
MDL number:
MFCD00269931
Assay:
≥98% (TLC)
Form:
solid
Quality level:
200
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产品名称

O6-苄基鸟嘌呤, ≥98% (TLC), solid

Quality Level

200

assay

≥98% (TLC)

form

solid

solubility

methanol: 20 mg/mL

storage temp.

room temp

SMILES string

Nc1nc(OCc2ccccc2)c3nc[nH]c3n1

InChI

1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)

InChI key

KRWMERLEINMZFT-UHFFFAOYSA-N

Gene Information

human ... MGMT(4255)

Application

使用O6-苄基鸟嘌呤：
  • 用作胶质母细胞瘤干细胞中甲基鸟嘌呤甲基转移酶(MGMT)抑制剂
  • 在N-乙基-N-亚硝基脲(ENU)疗法之前用作胚胎干细胞中的O6-烷基鸟嘌呤-烷基转移酶(AGT)的酶抑制剂
  • 在HL-60人早幼粒白血病生长抑制试验中AGT的抑制剂

Biochem/physiol Actions

O6-苄基鸟嘌呤(O6BG)可通过苄基转移阻断活性部位来抑制甲基鸟嘌呤甲基转移酶(MGMT)。使用O6BG与双氯乙基亚硝基脲(BCNU)或卡莫司汀治疗包括淋巴瘤、黑色素瘤和肉瘤等实体肿瘤是有效的。
O(6)-苄基鸟嘌呤是一种抗肿瘤剂，它通过与DNA修复酶O(6)-烷基鸟嘌呤DNA烷基转移酶（AGT）结合，抑制AGT介导的DNA修复。它被广泛用于各种DNA修复机制研究，并且可加强其他破坏DNA的化疗药物的作用。

pictograms

Exclamation mark
GHS07

signalword

Warning

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
049M4094V
13180907
127M4097V
13170703
047M4029V

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全球贸易项目编号

货号GTIN
B2292-50MG04061833020623